ArticleGenes and immunity2007
Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Tnni3k Is Cardioprotective in Viral Myocarditis.Journal of cardiovascular development and disease · 2026Article
- IL-33/ST2 Signaling Protects the Heart by Restraining Inflammation and Parasite Burden duringACS infectious diseases · 2026Article
- A murine model ofMicrobiology spectrum · 2025Article
- A murine model ofbioRxiv : the preprint server for biology · 2024Article
- Immunopathogenesis and immunomodulatory therapy for myocarditis.Science China. Life sciences · 2023Review
- Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy.Frontiers in pharmacology · 2023Article
- Molecular and Conventional Analysis of Acute Diarrheal Isolates Identifies Epidemiological Trends, Antibiotic Resistance and Virulence Profiles of Common Enteropathogens in Shanghai.Frontiers in microbiology · 2018Article
- Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication.PLoS pathogens · 2017Article
- Cardiac Autoimmunity: Myocarditis.Advances in experimental medicine and biology · 2017Review
- Mapping of a quantitative trait locus controlling susceptibility to Coxsackievirus B3-induced viral hepatitis.Genes and immunity · 2015Article
- Unusual rotavirus genotypes among children with acute diarrhea in Saudi Arabia.BMC infectious diseases · 2015Article
- Reduced MCMV Δm157 viral clearance in the absence of TSAd.Scientific reports · 2015Article
- Unc93b1 -Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection.Journal of innate immunity · 2015Article
- Cyclosporine A Treatment Inhibits Abcc6-Dependent Cardiac Necrosis and Calcification following Coxsackievirus B3 Infection in Mice.PloS one · 2015Article
- Tnni3k modifies disease progression in murine models of cardiomyopathy.PLoS genetics · 2009Article
- A locus on chromosome 1 promotes susceptibility of experimental autoimmune myocarditis and lymphocyte cell death.Clinical immunology (Orlando, Fla.) · 2009Article
- Genetic differences in bone marrow-derived lymphoid lineages control susceptibility to experimental autoimmune myocarditis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Chemical mutagenesis: a new strategy against the global threat of infectious diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Review
- Genetic complexity of autoimmune myocarditis.Autoimmunity reviews · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. We have used a model of infection with coxsackievirus B3 (CVB3) to characterize the contribution of host genetics to viral myocarditis in mice of different genetic backgrounds but with a common H2 haplotype: A/J and B10.A-H2(a). Here we have used Evans blue dye as a quantitative biomarker for susceptibility to CVB3-induced myocarditis in addition to histopathological semiquantitative measures. We have found evidence of linkage between susceptibility to viral myocarditis and three loci. A locus on chromosome 1 centered on D1Mit200 was linked to sarcolemmal disruption in males (P=0.00005), a second locus on chromosome 4 centered on D4Mit81 was also linked to sarcolemmal disruption in males (P=0.0022). A third locus on distal chromosome 3 centered on D3Mit19 was linked to myocardial infiltration, with a logarithm of odds (LOD) score of 4.7 (P=0.0045), as well as sarcolemmal disruption in females (P=0.0015). These results provide strong evidence for the presence of loci contributing to the susceptibility of mice to viral myocarditis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.