ArticleNature2007
An African origin for the intimate association between humans and Helicobacter pylori.
Article in Nature, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 450 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
450 citing papers in PubMed, 1 synthesis or guideline pooled it, 977 citations in OpenAlex.
- AGA Clinical Practice Update on the Management of Refractory Helicobacter pylori Infection: Expert Review.Gastroenterology · 2021Guideline
- Ten-day concomitant and sequential therapy for Helicobacter pylori effective in region with high antibiotic resistance rates.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Trial
- Sequential eradication of Helicobacter pylori as a treatment for immune thrombocytopenia in patients with moderate thrombocytopenia: a multicenter prospective randomized phase 3 study.Annals of hematology · 2022Trial
- A link between platelet to lymphocyte ratio and Helicobacter pylori infection.Journal of clinical laboratory analysis · 2018Trial
- Host andGut microbes · 2026Article
- Gut microbes that trace ancient human journeys.Nature · 2026Article
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- Gastric Microbiota from Populations with High Risk of Gastric Cancer in Nariño, Colombia.International journal of molecular sciences · 2026Article
- Molecular Characterization and Genetic Diversity ofDiagnostics (Basel, Switzerland) · 2026Article
- A model of Helicobacter infection using an artificial liver constructed by a radial-flow bioreactor.Human cell · 2026Article
- Genomic characterization of clinical Helicobacter pylori strains from Korea: insights into phylogeny, pan-genome structure, and virulence factors.BMC microbiology · 2026Article
- Genomic-microbial coevolution in human development: chromosome 2 fusion, and human accelerated regions.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
- Assembly and glycosylation ofPNAS nexus · 2026Article
- Molecular characterization of fourGut microbes · 2025Article
- Review
- Bacterial generalists and fungal specialists play important roles in maintaining community stability and regulating microbial diversity of the algae-associated microbiome throughout the growth cycle ofApplied and environmental microbiology · 2025Article
- Characteristics of Gastric Endoscopic and Histopathological Findings in the South and Southeast Asian Populations.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Global diversity of integrating conjugative elements (ICEs) inbioRxiv : the preprint server for biology · 2025Article
390 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
Abstract
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic differentiation, the age of an association between these bacteria with humans remains highly controversial. Here we show, using sequences from a large data set of bacterial strains that, as in humans, genetic diversity in H. pylori decreases with geographic distance from east Africa, the cradle of modern humans. We also observe similar clines of genetic isolation by distance (IBD) for both H. pylori and its human host at a worldwide scale. Like humans, simulations indicate that H. pylori seems to have spread from east Africa around 58,000 yr ago. Even at more restricted geographic scales, where IBD tends to become blurred, principal component clines in H. pylori from Europe strongly resemble the classical clines for Europeans described by Cavalli-Sforza and colleagues. Taken together, our results establish that anatomically modern humans were already infected by H. pylori before their migrations from Africa and demonstrate that H. pylori has remained intimately associated with their human host populations ever since.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.