ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia.Brain : a journal of neurology · 2025Article
- Resveratrol Prevents Cell Swelling Through Inhibition of SUR1 Expression in Brain Micro Endothelial Cells Subjected to OGD/Recovery.Molecular neurobiology · 2024Article
- Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation.Frontiers in molecular neuroscience · 2023Article
- P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.Cell and tissue research · 2022Review
- Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype.Molecular neurobiology · 2018Article
- Expression and Function of hsa-miR-6165 in Human Cell Lines and During the NT2 Cell Neural Differentiation Process.Journal of molecular neuroscience : MN · 2017Article
- Overexpression of hsa-miR-939 follows by NGFR down-regulation and apoptosis reduction.Journal of biosciences · 2017Article
- Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies.International journal of molecular sciences · 2017Review
- Implication of the neurotrophin receptor p75Expert review of ophthalmology · 2017Article
- Isolation and Characterization of Ischemia-Derived Astrocytes (IDAs) with Ability to Transactivate Quiescent Astrocytes.Frontiers in cellular neuroscience · 2016Article
- The Role of Astrocytic Aquaporin-4 in Synaptic Plasticity and Learning and Memory.Frontiers in integrative neuroscience · 2016Review
- Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression.Biochimie · 2015Article
- Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.The Journal of clinical investigation · 2014Article
- VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling.Stem cell research · 2014Article
- Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75(NTR) and sortillin.Neuroscience · 2014Article
- Article
- Aquaporin-4 water channels and synaptic plasticity in the hippocampus.Neurochemistry international · 2013Review
- p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.Cell death & disease · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury-induced expression of the p75 neurotrophin receptor (p75NTR) in the CNS facilitates neuronal apoptosis and prevents neuronal regrowth, but the mechanisms regulating p75NTR expression are poorly characterized. In this study, we showed that hypo-osmolarity induces p75NTR expression in primary neurons, and, using a comparative genomics approach, we identified conserved elements in the 25 kb upstream sequences of the rat, mouse, and human p75NTR genes. We found that only one of these, a proximal region rich in Sp1 sites, responds to changes in hypo-osmolarity. We then showed that Sp1 DNA binding activity is increased in cells exposed to hypo-osmolarity, established that hypo-osmolarity enhanced Sp1 binding to the endogenous p75NTR promoter, and showed that Sp1 is required for p75NTR expression induced by hypo-osmolarity. We examined how Sp1 is regulated to effect these changes and established that Sp1 turnover is strongly inhibited by hypo-osmolarity. We propose that stress-induced Sp1 accumulation that results from reductions in Sp1 turnover rate contributes to injury-induced gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.