ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Xenopus vocalizations are controlled by a sexually differentiated hindbrain central pattern generator.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Convergent and divergent neural circuit architectures that support acoustic communication.Frontiers in neural circuits · 2022Pooled it
- Timescales of call variability in a South American treefrog.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- The Use of Cognition by Amphibians Confronting Environmental Change: Examples from the Behavioral Ecology of Crawfish Frogs (Animals : an open access journal from MDPI · 2025Article
- Gekko gecko as a model organism for understanding aspects of laryngeal vocal evolution.The Journal of experimental biology · 2024Article
- Cetaceans are the next frontier for vocal rhythm research.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The neurobiology of vocal communication in marmosets.Annals of the New York Academy of Sciences · 2023Review
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- Article
- Mapping the vocal circuitry of Alston's singing mouse with pseudorabies virus.The Journal of comparative neurology · 2022Article
- Vocal and Electric Fish: Revisiting a Comparison of Two Teleost Models in the Neuroethology of Social Behavior.Frontiers in neural circuits · 2021Review
- Molecular characterization of frog vocal neurons using constellation pharmacology.Journal of neurophysiology · 2020Article
- Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Auditory perception exhibits sexual dimorphism and left telencephalic dominance inBiology open · 2018Article
- Premotor Neuron Divergence Reflects Vocal Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Inhibitory and modulatory inputs to the vocal central pattern generator of a teleost fish.The Journal of comparative neurology · 2018Article
- Oviposition-like central pattern generators in pregenital segments of male and female grasshoppers.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Development of an Acute Method to Deliver Transgenes Into the Brains of AdultFrontiers in neural circuits · 2018Article
- Motor Neurons Tune Premotor Activity in a Vertebrate Central Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Evolution of vocal patterns: tuning hindbrain circuits during species divergence.The Journal of experimental biology · 2017Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Male and female African clawed frogs (Xenopus laevis) produce rhythmic, sexually distinct vocalizations as part of courtship and mating. We found that Xenopus vocal behavior is governed by a sexually dimorphic central pattern generator (CPG) and that fictive vocalizations can be elicited from an in vitro brain preparation by application of serotonin or by electrical stimulation of a premotor nucleus. Male brains produced fictive vocal patterns representing two calls commonly produced by males in vivo (advertisement and amplectant call), as well as one call pattern (release call) that is common for juvenile males and females in vivo but rare for adult males. Female brains also produced fictive release call. The production of male calls is androgen dependent in Xenopus; to test the effects of androgens on the CPG, we examined fictive calling in the brains of testosterone-treated females. Both fictive male advertisement call and release call were produced. This suggests that all Xenopus possess a sexually undifferentiated pattern generator for release call. Androgen exposure leads to a gain-of-function, allowing the production of male-specific call types without prohibiting the production of the undifferentiated call pattern. We also demonstrate that the CPG is located in the brainstem and seems to rely on the same nuclei in both males and females. Finally, we identified endogenous serotonergic inputs to both the premotor and motor nuclei in the brainstem that may regulate vocal activity in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.