ArticleMolecular biology of the cell2007
Evolution of a tumorigenic property conferred by glycophosphatidyl-inositol membrane anchors of carcinoembryonic antigen gene family members during the primate radiation.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model.Frontiers in immunology · 2026Article
- New World Primates and Their Human Counterparts Share Diseases That Abound with CEACAM and Other Effector Molecules.Life (Basel, Switzerland) · 2025Review
- The emerging roles of CEACAM6 in human cancer (Review).International journal of oncology · 2024Review
- GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway.Journal of experimental & clinical cancer research : CR · 2019Article
- Evaluation of neurotensin receptor 1 as a potential imaging target in pancreatic ductal adenocarcinoma.Amino acids · 2017Article
- Avoiding hepatic metastasis naturally: Lessons from the cotton top tamarin (Saguinus oedipus).World journal of gastroenterology · 2016Review
- A comprehensive phylogenetic and structural analysis of the carcinoembryonic antigen (CEA) gene family.Genome biology and evolution · 2014Article
- Regulation gene expression of miR200c and ZEB1 positively enhances effect of tumor vaccine B16F10/GPI-IL-21 on inhibition of melanoma growth and metastasis.Journal of translational medicine · 2014Article
- Antitumor efficacy of viable tumor vaccine modified by heterogenetic ESAT-6 antigen and cytokine IL-21 in melanomatous mouse.Immunologic research · 2012Article
- The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors.International journal of cancer · 2011Review
- Colorectal cancer in the cotton top tamarin (Saguinus oedipus): how do they evade liver metastasis?Digestive diseases and sciences · 2011Article
- Review
- The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers.Biomarkers in medicine · 2010Article
- Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families.BMC biology · 2010Article
- Recent advances in the tumour biology of the GPI-anchored carcinoembryonic antigen family members CEACAM5 and CEACAM6.Current oncology (Toronto, Ont.) · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GPI membrane anchors of cell surface glycoproteins have been shown to confer functional properties that are different from their transmembrane (TM)-anchored counterparts. For the human carcinoembryonic antigen (CEA) family, a subfamily of the immunoglobulin superfamily, conversion of the mode of membrane linkage from TM to GPI confers radical changes in function: from tumor suppression or neutrality toward inhibition of differentiation and anoikis and distortion of tissue architecture, thereby contributing to tumorigenesis. We show here that GPI anchorage in the CEA family evolved twice independently in primates, very likely from more primitive TM anchors, by different packages of mutations. Both mutational packages, one package found in many primates, including humans, and a second, novel package found only in the Cebidae radiation of New World monkeys, give rise to efficiently processed GPI-linked proteins. Both types of GPI anchors mediate inhibition of cell differentiation. The estimated rate of nonsynonymous mutations (Ka) in the anchor-determining domain for conversion from TM to GPI anchorage in the CEA family that were fixed during evolution in these primates is 7 times higher than the average Ka in primates, indicating positive selection. These results suggest therefore that the functional changes mediated by CEA GPI anchors, including the inhibition of differentiation and anoikis, could be adaptive and advantageous.
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