ArticleBiochemical and biophysical research communications2007
Expression of skeletal muscle Na(V)1.4 Na channel isoform in canine cardiac Purkinje myocytes.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
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- Reduced NaAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels.Current molecular pharmacology · 2015Review
- Silencing the NR2B gene in rat ACC neurons by lentivirus-delivered shRNA alleviates pain-related aversion.International journal of clinical and experimental medicine · 2015Article
- Voltage-gated sodium channels in the mammalian heart.Global cardiology science & practice · 2014Review
- DIFFERENCES IN IONIC CURRENTS BETWEEN CANINE MYOCARDIAL AND PURKINJE CELLS.Physiological reports · 2013Article
- Post-partum variation in the expression of paternal care is unrelated to urinary steroid metabolites in marmoset fathers.Hormones and behavior · 2013Article
- Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart.Pediatric research · 2011Article
- A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.The Journal of physiology · 2010Article
- Effects of tetrodotoxin on the mammalian cardiovascular system.Marine drugs · 2010Review
- Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.Biochemistry · 2010Article
- Silencing of Cav1.2 gene in neonatal cardiomyocytes by lentiviral delivered shRNA.Biochemical and biophysical research communications · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimThe action potential plateau of Purkinje fibers is particularly sensitive to tetrodotoxin (TTX) and this could be due to a TXX-sensitive Na(+) current. The expression of TTX-sensitive neuronal Na(V)1.1 and Na(V)1.2 isoforms has been reported in canine Purkinje myocytes. Our aim was to investigate by means of biochemical and functional techniques whether the TTX-sensitive skeletal Na(V)1.4 isoform is also expressed in canine cardiac Purkinje myocytes. METHODS AND
resultsUsing Na(V)1.4 specific primers, a PCR product corresponding to Na(V)1.4 was amplified from canine Purkinje fibers RNA and confirmed by sequencing and megablast of the gene bank. Confocal indirect immunostaining using anti-Na(V)1.4 antibody demonstrates distinct sarcolemmal staining pattern compared to that of the cardiac isoform Na(V)1.5. Expression of Na(V)1.4 in tsA201 cells yielded a TTX-sensitive Na(+) current with an IC(50) of 10nM.
conclusionsThese results demonstrate the expression of the TTX-sensitive Na(V)1.4 channel in canine cardiac Purkinje myocytes. This novel finding suggests a role of Na(V)1.4 channel in Purkinje myocytes and thus has important clinical implications for the mechanisms and management of ventricular arrhythmias originating in the Purkinje network.
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