ArticleClinical and experimental immunology2007
Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals.
Article in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Effects of Periodontal Treatment on Levels of Proinflammatory Cytokines in Patients with Chronic Periodontitis: A Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies.Disease markers · 2016Pooled it
- Circulating interleukin-6 and cancer: A meta-analysis using Mendelian randomization.Scientific reports · 2015Pooled it
- Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis.Molecular biology reports · 2013Pooled it
- Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis.Journal of Zhejiang University. Science. B · 2009Pooled it
- Article
- Periodontal disease as a model to study chronic inflammation in aging.GeroScience · 2024Review
- Radiation therapy for head and neck cancer leads to gingival recession associated with dental caries.Oral surgery, oral medicine, oral pathology and oral radiology · 2022Observational
- Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease.Journal of clinical medicine · 2020Review
- Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview.BMC oral health · 2019Review
- IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women.PeerJ · 2018Article
- Role of Thr399Ile and Asp299Gly polymorphisms of toll-like receptor-4 gene in acute dental abscess.Journal of clinical and experimental dentistry · 2017Article
- Association between IFN-γ +874A/T and IFN-γR1 (-611A/G, +189T/G, and +95C/T) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population.International journal of dentistry · 2015Article
- Destructive effects of smoking on molecular and genetic factors of periodontal disease.Tobacco induced diseases · 2010Article
- Gene polymorphisms in chronic periodontitis.International journal of dentistry · 2010Article
- Epigenetics and periodontal disease: future perspectives.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Review
- TNFA and IL10 gene polymorphisms are not associated with periodontitis in Brazilians.The open dentistry journal · 2009Article
- Correlation of interleukin-6-174 GC and interleukin-6-572 GC gene polymorphisms with periodontal disease in an Iranian population.Dental research journalArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL)-6 is an inflammatory mediator involved in bone resorption. G/C polymorphism at position -174 of the IL-6 gene has been reported to influence IL-6 expression, with the G allele associated with higher expression levels. The aims of this study were to investigate the expression of IL-6 as well as the incidence of IL-6 (-174) gene polymorphism and their correlation to the severity of periodontitis in Brazilians. Peripheral blood mononuclear cells were collected from 12 non-smoker individuals with periodontitis for evaluation of IL-6 expression using flow cytometry. We observed a positive correlation between the mean clinical attachment loss and intensity of expression of IL-6, in which the greater the attachment loss, the higher the expression of IL-6 (P=0 x 007, R2=0 x 52). Also, patients with severe periodontitis displayed a higher intensity of IL-6 expression compared to moderate periodontitis (P=0 x 04). To determine the occurrence of IL-6 gene polymorphism, DNA was obtained from oral swabs of 209 Brazilian individuals with and without periodontitis. Polymerase chain reaction, restriction endonuclease digestion and electrophoresis were performed, allowing for detection of the IL-6 (-174) polymorphism. We observed that non-smokers with moderate periodontitis (P=0 x 05) and control (P=0 x 04) groups displayed a higher incidence of the G genotype when compared to severe periodontitis. This suggests that the G genotype may represent a protective role in severity of periodontitis. Thus, the increased expression of IL-6 and IL-6 (-174) polymorphism are associated with periodontal disease severity in Brazilian individuals.
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