ReviewJournal of mammary gland biology and neoplasia2007
Extracellular proteolysis in transgenic mouse models of breast cancer.
Review in Journal of mammary gland biology and neoplasia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy.Cancers · 2021Review
- Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- Article
- Pulsed Terahertz Reflection Imaging of tumors in a spontaneous model of breast cancer.Biomedical physics & engineering express · 2018Article
- D2A sequence of the urokinase receptor induces cell growth through αvβ3 integrin and EGFR.Cellular and molecular life sciences : CMLS · 2018Article
- The Effect of Mammary Extracellular Matrix in Controlling Oral and Mammary Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Review
- A hybrid model of tumor-stromal interactions in breast cancer.Bulletin of mathematical biology · 2013Article
- Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation.Clinical & experimental metastasis · 2013Article
- Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer.Breast cancer research : BCR · 2013Article
- No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.PloS one · 2012Article
- Live-cell imaging of tumor proteolysis: impact of cellular and non-cellular microenvironment.Biochimica et biophysica acta · 2012Review
- TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.PloS one · 2012Article
- Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer.Journal of mammary gland biology and neoplasia · 2010Review
- Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.Microbiology and molecular biology reviews : MMBR · 2009Review
- The role of cathepsins in involution and breast cancer.Journal of mammary gland biology and neoplasia · 2009Article
- Mammary involution and breast cancer risk: transgenic models and clinical studies.Journal of mammary gland biology and neoplasia · 2009Review
- Imaging and quantifying the dynamics of tumor-associated proteolysis.Clinical & experimental metastasis · 2009Review
- Article
- Stromal induction of breast cancer: inflammation and invasion.Reviews in endocrine & metabolic disorders · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth and invasion of breast cancer require extracellular proteolysis in order to physically restructure the tissue microenvironment of the mammary gland. This pathological tissue remodeling process depends on a collaboration of epithelial and stromal cells. In fact, the majority of extracellular proteases are provided by stromal cells rather than cancer cells. This distinct expression pattern is seen in human breast cancers and also in transgenic mouse models of breast cancer. The similar expression patterns suggest that transgenic mouse models are ideally suited to study the role of extracellular proteases in cancer progression. Here we give a status report on protease intervention studies in transgenic models. These studies demonstrate that proteases are involved in all stages of breast cancer progression from carcinogenesis to metastasis. Transgenic models are now beginning to provide vital mechanistic insight that will allow us to combat breast cancer invasion and metastasis with new protease-targeted drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.