ArticleImmunogenetics2007
Complexity in the cattle CD94/NKG2 gene families.
Article in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Evidence of functional Cd94 polymorphism in a free-living house mouse population.Immunogenetics · 2019Article
- The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex.Frontiers in immunology · 2019Article
- The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation.Immunogenetics · 2017Article
- Cattle NK Cell Heterogeneity and the Influence of MHC Class I.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Definition of the cattle killer cell Ig-like receptor gene family: comparison with aurochs and human counterparts.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Constraints on haplotype structure and variable gene frequencies suggest a functional hierarchy within cattle MHC class I.Immunogenetics · 2012Article
- Comparative analysis of NK-cell receptor expression and function across primate species: Perspective on antiviral defenses.Self/nonself · 2010Article
- NK gene complex dynamics and selection for NK cell receptors.Seminars in immunology · 2008Review
- Genomic location and characterisation of MIC genes in cattle.Immunogenetics · 2008Article
- Genomic location and characterisation of nonclassical MHC class I genes in cattle.Immunogenetics · 2008Article
- Variation in the ligand binding domains of the CD94/NKG2 family of receptors in the squirrel monkey.Immunogenetics · 2007Article
- Complexity in cattle KIR genes: transcription and genome analysis.Immunogenetics · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer cell responses are controlled to a large extent by the interaction of an array of inhibitory and activating receptors with their ligands. The mostly nonpolymorphic CD94/NKG2 receptors in both humans and mice were shown to recognize a single nonclassical MHC class I molecule in each case. In this paper, we describe the CD94/NKG2 gene family in cattle. NKG2 and CD94 sequences were amplified from cDNA derived from four animals. Four CD94 sequences, ten NKG2A, and three NKG2C sequences were identified in total. In contrast to human, we show that cattle have multiple distinct NKG2A genes, some of which show minor allelic variation. All of the sequences designated NKG2A have two tyrosine-based inhibitory motifs in the cytoplasmic domain and one putative gene has, in addition, a charged residue in the transmembrane domain. NKG2C appears to be essentially monomorphic in cattle. All of the NKG2A sequences are similar apart from NKG2A-01, which, in contrast, shares the majority of its carbohydrate recognition domain with NKG2-C. Most of the genes appear to generate multiple alternatively spliced forms. These findings suggest that the CD94/NKG2A heterodimers in cattle, in contrast to other species, are binding several different ligands. Because NKG2C is not polymorphic, this raises questions as to the combined functional capacity of the CD94/NKG2 gene families in cattle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.