ArticleBritish journal of cancer2007
Malignant germ cell tumours of childhood: new associations of genomic imbalance.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Management of andrological disorders from childhood and adolescence to transition age: guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS) in collaboration with the Italian Society for Pediatric Endocrinology and Diabetology (SIEDP) - part-2.Journal of endocrinological investigation · 2026Article
- Yolk Sac Elements in Tumors Derived from Pluripotent Stem Cells: Borrowing Knowledge from Human Germ Cell Tumors.International journal of molecular sciences · 2025Review
- A matter of new life and cell death: programmed cell death in the mammalian ovary.Journal of biomedical science · 2024Review
- Mature Teratoma with Somatic-Type Malignancy: An Entity of Unacquaintance-A Case Report.Asian journal of neurosurgery · 2023Article
- Review
- Review
- Clonal diversification and histogenesis of malignant germ cell tumours.Nature communications · 2022Article
- Review
- Molecular and epigenetic pathogenesis of germ cell tumors.Asian journal of urology · 2021Review
- Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets.Communications biology · 2020Article
- Human germ cell tumours from a developmental perspective.Nature reviews. Cancer · 2019Review
- Pediatric Germ Cell Tumors: A Developmental Perspective.Advances in urology · 2018Review
- Review
- Expression pattern of clinically relevant markers in paediatric germ cell- and sex-cord stromal tumours is similar to adult testicular tumours.Virchows Archiv : an international journal of pathology · 2014Article
- Mixed malignant germ cell tumour of third ventricle with hydrocephalus: a rare case with recurrence.Journal of clinical and diagnostic research : JCDR · 2014Article
- Neuroendocrine carcinoma in a mediastinal teratoma as a rare variant of somatic-type malignancy.Virchows Archiv : an international journal of pathology · 2013Article
- LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels.Cancer research · 2013Article
- Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis.Endocrine reviews · 2013Review
- Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors.Pediatric blood & cancer · 2012Article
- Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant germ cell tumours (MGCTs) of childhood are a rare group of neoplasms that comprise many histological subtypes and arise at numerous different sites. Genomic imbalances have been described in these tumours but, largely because of the paucity of cases reported in the literature, it is unclear how they relate to abnormalities in adult MGCTs and impact on potential systems for classifying GCTs. We have used metaphase-based comparative genomic hybridisation to analyse the largest series of paediatric MGCTs reported to date, representing 34 primary tumours (22 yolk sac tumours (YSTs), 11 germinomatous tumours and one metastatic embryonal carcinoma) occurring in children from birth to age 16, including 17 ovarian MGCTs. The large dataset enabled us to undertake statistical analysis, with the aim of identifying associations worthy of further investigation between patterns of genomic imbalance and clinicopathological parameters. The YSTs showed an increased frequency of 1p- (P=0.003), 3p+ (P=0.02), 4q- (P=0.07) and 6q- (P=0.004) compared to germinomatous tumours. Gain of 12p, which is invariably seen in adult MGCTs, was present in 53% of primary MGCTs of children aged 5-16 and was also observed in four of 14 YSTs affecting children less than 5. Two of these cases (14% of MGCTs in children less than 5) showed gain of the 12p11 locus considered to be particularly relevant in adult MGCTs. Gain of 12p showed a significant association with gain of 12q. Conversely, MGCTs without 12p gain displayed a significantly increased frequency of loss on 16p (P=0.04), suggesting that this imbalance may contribute to tumour development in such cases. This data provides new insight into the biology of this under-investigated tumour group and will direct future studies on the significance of specific genetic abnormalities.
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