ArticleProceedings of the National Academy of Sciences of the United States of America2007
Direct action of gonadotropin in brain integrates behavioral and reproductive functions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Convergent and divergent neural circuit architectures that support acoustic communication.Frontiers in neural circuits · 2022Pooled it
- Visfatin in the porcine pituitary gland: expression and regulation of secretion during the oestrous cycle and early pregnancy.Scientific reports · 2023Article
- Petroleum-derived naphthenic acids disrupt hormone-dependent sexual behaviours in male Western clawed frogs.Conservation physiology · 2022Article
- Luteinizing hormone and the aging brain.Vitamins and hormones · 2021Review
- Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- CNS luteinizing hormone receptor activation rescues ovariectomy-related loss of spatial memory and neuronal plasticity.Neurobiology of aging · 2019Article
- Reproductive State Modulates Retinal Sensitivity to Light in Female Túngara Frogs.Frontiers in behavioral neuroscience · 2019Article
- Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss.Frontiers in endocrinology · 2018Review
- Neuroendocrine-immune circuits, phenotypes, and interactions.Hormones and behavior · 2017Review
- Luteinizing hormone downregulation but not estrogen replacement improves ovariectomy-associated cognition and spine density loss independently of treatment onset timing.Hormones and behavior · 2016Article
- Luteinizing hormone: Evidence for direct action in the CNS.Hormones and behavior · 2015Review
- Hypothalamic-pituitary-gonadal axis involvement in learning and memory and Alzheimer's disease: more than "just" estrogen.Frontiers in endocrinology · 2015Review
- Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians.PloS one · 2015Article
- Neuromolecular responses to social challenge: common mechanisms across mouse, stickleback fish, and honey bee.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Harnessing vocal patterns for social communication.Current opinion in neurobiology · 2014Review
- The Xenopus amygdala mediates socially appropriate vocal communication signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Distinct expression patterns of glycoprotein hormone subunits in the lophotrochozoan Aplysia: implications for the evolution of neuroendocrine systems in animals.Endocrinology · 2012Article
- Estrogens can disrupt amphibian mating behavior.PloS one · 2012Article
- A neuroendocrine basis for the hierarchical control of frog courtship vocalizations.Frontiers in neuroendocrinology · 2011Review
- Vocal pathway degradation in gonadectomized Xenopus laevis adults.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Essential roles for gonadotropins in gonadal development and reproduction are well established. Over the past decade, however, the expression of luteinizing hormone receptor (LHR) has also been reported in the brain of various mammals and birds. Although suggestive, it has not yet been determined whether this expression pattern supports a novel function for gonadotropins. Here, we demonstrate a CNS-mediated role of gonadotropins in a reproductive behavior: the courtship songs of the South African clawed frog, Xenopus laevis. Male advertisement calling in this species depends on a nongonadal action of gonadotropin. To determine whether this effect is due to action on the CNS, we administered gonadotropin intracerebroventricularly (ICV) or systemically to intact or castrated males with or without concomitant androgen replacement. In intact and androgen-replaced gonadectomized males, gonadotropin significantly increased calling within 1 h after ICV injection. The effective dosage via ICV injections was less than one hundredth of the effective systemic dose. In situ hybridization with a cloned fragment of Xenopus LHR revealed strong expression in ventral forebrain areas important for vocal control. Further, gonadotropin treatment of brain in vitro up-regulates immunoreactivity for the LHR downstream target, egr-1, specifically in these vocal forebrain areas. Up-regulation occurs even when synaptic transmission is suppressed by incubation in Ca2+ free/high magnesium saline. These results demonstrate a neural role for gonadotropin in the control of calling behavior, potentially mediated via LHRs in forebrain vocal nuclei. Gonadotropin may play a novel integrative role in modulating both reproductive physiology and behavior.
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