ArticleArchives of disease in childhood2007
Variation in policies for the management of febrile neutropenia in United Kingdom Children's Cancer Study Group centres.
Article in Archives of disease in childhood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Guideline
- Predicting microbiologically defined infection in febrile neutropenic episodes in children: global individual participant data multivariable meta-analysis.British journal of cancer · 2016Pooled it
- Outpatient and oral antibiotic management of low-risk febrile neutropenia are effective in children--a systematic review of prospective trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Pooled it
- Pooled it
- Pooled it
- Systematic review and meta-analysis of the discriminatory performance of risk prediction rules in febrile neutropaenic episodes in children and young people.European journal of cancer (Oxford, England : 1990) · 2010Pooled it
- Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT.Health technology assessment (Winchester, England) · 2024Trial
- Factors contributing to the non-identification of bacterial meningitis in febrile infants: A case series study.SAGE open medical case reports · 2024Article
- Once-a-Day Ceftriaxone-Amikacin Combination as Empiric Antibiotic Therapy to Enable Outpatient Management of Febrile Neutropenia in Children-16-Year Experience from a Single Institute.South Asian journal of cancer · 2022Article
- A Dynamic Approach for Early Risk Prediction of Gram-Negative Bloodstream Infection and Systemic Inflammatory Response Syndrome in Febrile Pediatric Hemato-Oncology Patients.Children (Basel, Switzerland) · 2022Article
- Examining health-related quality of life in pediatric cancer patients with febrile neutropenia: Factors predicting poor recovery in children and their parents.EClinicalMedicine · 2021Article
- Article
- Prospective cohort study of procalcitonin levels in children with cancer presenting with febrile neutropenia.BMC pediatrics · 2017Article
- Bloodstream infection in paediatric cancer centres--leukaemia and relapsed malignancies are independent risk factors.European journal of pediatrics · 2015Article
- The influence of different fever definitions on the rate of fever in neutropenia diagnosed in children with cancer.PloS one · 2015Article
- Variation in Management of Fever and Neutropenia Among Pediatric Patients With Cancer: A Survey of Providers in Michigan.Pediatric hematology and oncology · 2015Article
- Diagnostic accuracy of lipopolysaccharide-binding protein for predicting bacteremia/clinical sepsis in children with febrile neutropenia: comparison with interleukin-6, procalcitonin, and C-reactive protein.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Article
- Developing a national 'low risk' febrile neutropenia framework for use in children and young people's cancer care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Predicting infectious complications in neutropenic children and young people with cancer (IPD protocol).Systematic reviews · 2012Review
- Outpatient management of febrile neutropenia in children with cancer.Pediatric reports · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the variation in the current UK management strategies for the treatment of febrile neutropenia in childhood. DESIGN AND
settingA postal survey of all 21 United Kingdom Children's Cancer Study Group (UKCCSG) centres assessing and collating local policies, protocols or guidelines relating to the management of febrile neutropenia. Further direct contact was undertaken to clarify any uncertainties.
resultsAll 21 centres provided information. The policies used to manage febrile neutropenia in the centres around the UK vary in almost every aspect of management. Definitions of fever ranged from a persistent temperature of >37.5 degrees C to a single reading of >39 degrees C. Neutropenia was inconsistently defined as an absolute neutrophil count of <1x10(9), <0.75x10(9 )or <0.5x10(9). Choices of antibiotic approaches, empirical modifications and antistaphylococcal treatment were different in each protocol. The use of risk stratification was undertaken in 11 centres, with six using a policy of reduced intensity therapy in low risk cases. Empirical antifungal treatment was very poorly described and varied even more widely.
conclusionsThere was a great deal of variation in definitions and treatment of febrile neutropenia in the UKCCSG children's cancer treatment centres. A degree of variation as a result of local microbiological differences is to be expected, but beyond this we should seek to standardise the core of our approach to defining fever and neutropenia, risk stratification and duration of empirical therapy in a way that maintains safety, minimises resource utilisation and maximises quality of life.
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