ArticleCardiovascular diabetology2007
Persistent hyperglycemia is an independent predictor of outcome in acute myocardial infarction.
Article in Cardiovascular diabetology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.
- Acute glycemic variability on admission predicts the prognosis in hospitalized patients with coronary artery disease: a meta-analysis.Endocrine · 2020Pooled it
- Metformin in non-diabetic patients presenting with ST elevation myocardial infarction: rationale and design of the glycometabolic intervention as adjunct to primary percutaneous intervention in ST elevation myocardial infarction (GIPS)-III trial.Cardiovascular drugs and therapy · 2012Trial
- The impact of a reduced dose of dexamethasone on glucose control after coronary artery bypass surgery.Cardiovascular diabetology · 2007Trial
- The role of stress hyperglycemia in in-hospital new-onset atrial fibrillation among patients with acute myocardial infarction: a narrative review.Frontiers in cardiovascular medicine · 2026Review
- Incremental Prognostic Value of Admission Blood Glucose to Albumin Ratio in Patients with Acute Coronary Syndrome: A Retrospective Observational Cohort Study.Reviews in cardiovascular medicine · 2025Article
- Glycemic Comparison Index (GCI): a retrospective analysis of its prognostic value in ICU patients with AMI and diabetes.BMC endocrine disorders · 2025Article
- PTH Predicts the in-Hospital MACE After Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction.Therapeutics and clinical risk management · 2023Article
- Short and long-term prognosis of admission hyperglycemia in patients with and without diabetes after acute myocardial infarction: a retrospective cohort study.Cardiovascular diabetology · 2022Article
- Association between intraoperative hyperglycemia and postoperative end-organ dysfunctions after cardiac surgery: a retrospective observational study.Journal of anesthesia · 2022Observational
- Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute pancreatitis.Frontiers in endocrinology · 2022Article
- The application of remote ischemic conditioning in cardiac surgery.F1000Research · 2017Review
- The effect of metformin on cardiovascular risk profile in patients without diabetes presenting with acute myocardial infarction: data from the Glycometabolic Intervention as adjunct to Primary Coronary Intervention in ST Elevation Myocardial Infarction (GIPS-III) trial.BMJ open diabetes research & care · 2015Article
- Far red/near infrared light-induced protection against cardiac ischemia and reperfusion injury remains intact under diabetic conditions and is independent of nitric oxide synthase.Frontiers in physiology · 2014Article
- Elective percutaneous coronary intervention: the relationship between preprocedural blood glucose levels and periprocedural myocardial injury.Texas Heart Institute journal · 2013Article
- Near-normal glycemia for critically ill patients receiving nutrition support: fact or folly.Current opinion in gastroenterology · 2010Review
- Neointimal hyperplasia persists at six months after sirolimus-eluting stent implantation in diabetic porcine.Cardiovascular diabetology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated blood glucose values are a prognostic factor in myocardial infarction (MI) patients. The unfavourable relation between hyperglycemia and outcome is known for admission glucose and fasting glucose after admission. These predictors are single measurements and thus not indicative of overall hyperglycemia. Increased persistent hyperglycemia may better predict adverse events in MI patients.
methodsIn a prospective study of MI patients treated with primary percutaneous coronary intervention (PCI) frequent blood glucose measurements were obtained to investigate the relation between glucose and the occurrence of major adverse cardiac events (MACE) at 30 days follow-up. MACE was defined as death, recurrent infarction, repeat primary coronary intervention, and left ventricular ejection fraction equal to or smaller than 30%.
resultsMACE occurred in 89 (21.3%) out 417 patients. In 17 patients (4.1%) it was a fatal event. A mean of 7.4 glucose determinations were available per patient. Mean +/- SD admission glucose was 10.1 +/- 3.7 mmol/L in patients with a MACE versus 9.1 +/- 2.7 mmol/L in event-free patients (P = 0.0024). Mean glucose during the first two days after admission was 9.0 +/- 2.8 mmol/L in patients with MACE compared to 8.1 +/- 2.0 mmol/L in event free patients (P < 0.0001). The area under the receiver operator characteristic curve was 0.64 for persistent hyperglycemia and 0.59 for admission glucose. Persistent hyperglycemia emerged as a significant independent predictor (P < 0.001).
conclusionPersistent hyperglycemia in MI has a stronger relation with 30-day MACE than elevated glucose at admission.
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