ArticleEmerging infectious diseases2006
Serotype competence and penicillin resistance in Streptococcus pneumoniae.
Article in Emerging infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A synopsis of competence-regulated virulence inVirulence · 2026Review
- Point mutations in functionally diverse genes are associated with increased natural DNA transformation in multidrug resistant Streptococcus pneumoniae.Nucleic acids research · 2025Article
- Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae.Nucleic acids research · 2023Article
- Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci.PLoS pathogens · 2018Article
- Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective.Clinical microbiology reviews · 2016Review
- Addiction of Hypertransformable Pneumococcal Isolates to Natural Transformation for In Vivo Fitness and Virulence.Infection and immunity · 2016Article
- Serotypes and genotypes of Streptococcus pneumoniae isolates from Trinidad and Tobago.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016Article
- Article
- Genome-Wide Fitness and Genetic Interactions Determined by Tn-seq, a High-Throughput Massively Parallel Sequencing Method for Microorganisms.Current protocols in microbiology · 2015Article
- Penicillin-Resistant trend of Streptococcus pneumoniae in Asia: A systematic review.Iranian journal of microbiology · 2014Review
- Tolerance of a phage element by Streptococcus pneumoniae leads to a fitness defect during colonization.Journal of bacteriology · 2014Article
- Heterogeneity in the frequency and characteristics of homologous recombination in pneumococcal evolution.PLoS genetics · 2014Article
- Genome-Wide Fitness and Genetic Interactions Determined by Tn-seq, a High-Throughput Massively Parallel Sequencing Method for Microorganisms.Current protocols in molecular biology · 2014Review
- Dense genomic sampling identifies highways of pneumococcal recombination.Nature genetics · 2014Article
- Significant variation in transformation frequency in Streptococcus pneumoniae.The ISME journal · 2013Article
- Clinical implications of pneumococcal serotypes: invasive disease potential, clinical presentations, and antibiotic resistance.Journal of Korean medical science · 2013Review
- Genome-wide fitness and genetic interactions determined by Tn-seq, a high-throughput massively parallel sequencing method for microorganisms.Current protocols in microbiology · 2010Article
- Comparison of transformation frequencies among selected Streptococcus pneumoniae serotypes.International journal of antimicrobial agents · 2010Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From 2003 to 2005, we prospectively collected 118 isolates of pneumococci belonging to 7 serotypes to investigate their competence under the influence of the synthetic competence-stimulating peptides. The degree of competence of the various serotypes differed significantly. Serotype 6B had the highest competence, followed by serotypes 14, 19F, 9V, 23F, 3, and 18C. Isolates belonging to serotype 6B had greater genetic diversity than isolates belonging to serotype 3, which has high genetic clustering. Isolates belonging to serotypes 3 and 18C that were 100% sensitive to penicillin were significantly less competent than isolates belonging to serotypes 6B, 14, 19F, 9V, and 23F, which were frequently resistant to penicillin. Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important.
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