ArticleThe Journal of cell biology2007
Formation of microtubule-based traps controls the sorting and concentration of vesicles to restricted sites of regenerating neurons after axotomy.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 91 citations in OpenAlex.
- Neuronal maturation and axon regeneration: unfixing circuitry to enable repair.Nature reviews. Neuroscience · 2024Review
- Mechanisms of Axon Growth and Regeneration: Moving between Development and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor.Cells · 2021Review
- Review
- Microtubule dynamics in healthy and injured neurons.Developmental neurobiology · 2021Review
- Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury.Military Medical Research · 2020Review
- Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration.iScience · 2020Article
- The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?Neurochemical research · 2020Review
- Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches.Developmental neurobiology · 2016Review
- Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury.Molecular & cellular proteomics : MCP · 2016Review
- Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans.F1000Research · 2016Review
- Article
- An assay to image neuronal microtubule dynamics in mice.Nature communications · 2014Article
- Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Laminar stream of detergents for subcellular neurite damage in a microfluidic device: a simple tool for the study of neuroregeneration.Journal of neural engineering · 2013Article
- Normal spastin gene dosage is specifically required for axon regeneration.Cell reports · 2012Article
- No simpler than mammals: axon and dendrite regeneration in Drosophila.Genes & development · 2012Article
- Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?Molecular psychiatry · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transformation of a transected axonal tip into a growth cone (GC) is a critical step in the cascade leading to neuronal regeneration. Critical to the regrowth is the supply and concentration of vesicles at restricted sites along the cut axon. The mechanisms underlying these processes are largely unknown. Using online confocal imaging of transected, cultured Aplysia californica neurons, we report that axotomy leads to reorientation of the microtubule (MT) polarities and formation of two distinct MT-based vesicle traps at the cut axonal end. Approximately 100 microm proximal to the cut end, a selective trap for anterogradely transported vesicles is formed, which is the plus end trap. Distally, a minus end trap is formed that exclusively captures retrogradely transported vesicles. The concentration of anterogradely transported vesicles in the former trap optimizes the formation of a GC after axotomy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.