ArticleInfection and immunity2007
Coinfection with Schistosoma mansoni reactivates viremia in rhesus macaques with chronic simian-human immunodeficiency virus clade C infection.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review.PLoS pathogens · 2021Pooled it
- Effects of parasites coinfection with other pathogens on animal host: A literature review.Veterinary world · 2022Review
- Assessment of schistosomiasis endemicity and preventive treatment on coronavirus disease 2019 outcomes in Africa.New microbes and new infections · 2020Article
- Novel Strategy To Adapt Simian-Human Immunodeficiency Virus E1 CarryingJournal of virology · 2018Article
- HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected WithFrontiers in immunology · 2018Article
- Schistosomiasis and Human Immunodeficiency Virus in Men in Tanzania.The American journal of tropical medicine and hygiene · 2017Article
- Macaque models of enhanced susceptibility to HIV.Virology journal · 2015Review
- Ungulates as model systems for the study of disease processes in natural populations.Journal of mammalogy · 2015Article
- The role played by alternative splicing in antigenic variability in human endo-parasites.Parasites & vectors · 2014Review
- Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose.Retrovirology · 2014Article
- Translation of biomedical prevention strategies for HIV: prospects and pitfalls.Journal of acquired immune deficiency syndromes (1999) · 2013Review
- Epidemiology and interactions of Human Immunodeficiency Virus - 1 and Schistosoma mansoni in sub-Saharan Africa.Infectious diseases of poverty · 2013Article
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
- The effects of schistosomiasis on HIV/AIDS infection, progression and transmission.Current opinion in HIV and AIDS · 2012Review
- Isolation of monoclonal antibodies with predetermined conformational epitope specificity.PloS one · 2012Article
- Schistosoma mansoni enhances host susceptibility to mucosal but not intravenous challenge by R5 Clade C SHIV.PLoS neglected tropical diseases · 2011Article
- Immune-based approaches to the prevention of mother-to-child transmission of HIV-1: active and passive immunization.Clinics in perinatology · 2010Article
- Oral infectious diseases: a potential risk factor for HIV virus recrudescence?Oral diseases · 2009Review
- IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Immunopathogenesis of asymptomatic chronic HIV Infection: the calm before the storm.Current opinion in HIV and AIDS · 2009Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
We tested the hypothesis that helminth parasite coinfection would intensify viremia and accelerate disease progression in monkeys chronically infected with an R5 simian-human immunodeficiency virus (SHIV) encoding a human immunodeficiency virus type 1 (HIV-1) clade C envelope. Fifteen rhesus monkeys with stable SHIV-1157ip infection were enrolled into a prospective, randomized trial. These seropositive animals had undetectable viral RNA and no signs of immunodeficiency. Seven animals served as virus-only controls; eight animals were exposed to Schistosoma mansoni cercariae. From week 5 after parasite exposure onward, coinfected animals shed eggs in their feces, developed eosinophilia, and had significantly higher mRNA expression of the T-helper type 2 cytokine interleukin-4 (P = 0.001) than animals without schistosomiasis. Compared to virus-only controls, viral replication was significantly increased in coinfected monkeys (P = 0.012), and the percentage of their CD4(+) CD29(+) memory cells decreased over time (P = 0.05). Thus, S. mansoni coinfection significantly increased viral replication and induced T-cell subset alterations in monkeys with chronic SHIV clade C infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.