ArticleMolecular and cellular biology2007
Beta-globin intergenic transcription and histone acetylation dependent on an enhancer.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Role of eRNAs in Cardiovascular Diseases.Current cardiology reviews · 2026Review
- Cell type-dependent directional transcription at enhancers.NAR genomics and bioinformatics · 2025Article
- Role of long non-coding RNA MALAT1 in chronic obstructive pulmonary disease.Experimental and therapeutic medicine · 2020Article
- The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription.Genes & development · 2018Article
- Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-β induction in patients with COPD.International journal of chronic obstructive pulmonary disease · 2016Article
- Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer.Diagnostic pathology · 2015Article
- Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus.Bioscience reports · 2015Article
- Systems biology of myasthenia gravis, integration of aberrant lncRNA and mRNA expression changes.BMC medical genomics · 2015Article
- Long noncoding RNA: significance and potential in skin biology.Cold Spring Harbor perspectives in medicine · 2014Review
- Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines.BMC genomics · 2014Article
- Boosting transcription by transcription: enhancer-associated transcripts.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Analysis of the enhancer-blocking function of the TBS element from Petunia hybrida in transgenic Arabidopsis thaliana and Nicotiana tabacum.Plant cell reports · 2011Article
- Review
- Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.Seminars in immunology · 2010Review
- Both the constitutive cauliflower mosaic virus 35S and tissue-specific AGAMOUS enhancers activate transcription autonomously in Arabidopsis thaliana.Plant molecular biology · 2010Article
- Association of differential and site-dependent CpG methylation and diverse expression of DNA methyltransferases with the tissue-specific expression of human beta-globin gene in transgenic mice.International journal of hematology · 2009Article
- BRG1 requirement for long-range interaction of a locus control region with a downstream promoter.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The apolipoprotein CIII enhancer regulates both extensive histone modification and intergenic transcription of human apolipoprotein AI/CIII/AIV genes but not apolipoprotein AV.The Journal of biological chemistry · 2008Article
- Noncoding RNA in development.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Review
- The role of transcriptional activator GATA-1 at human beta-globin HS2.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Histone acetyltransferases are associated with the elongating RNA polymerase II (Pol II) complex, supporting the idea that histone acetylation and transcription are intertwined mechanistically in gene coding sequences. Here, we studied the establishment and function of histone acetylation and transcription in noncoding sequences by using a model locus linking the beta-globin HS2 enhancer and the embryonic epsilon-globin gene in chromatin. An intact HS2 enhancer that recruits RNA Pol II is required for intergenic transcription and histone H3 acetylation and K4 methylation between the enhancer and target gene. RNA Pol II recruitment to the target gene TATA box is not required for the intergenic transcription or intergenic histone modifications, strongly implying that they are properties conferred by the enhancer. However, Pol II recruitment at HS2, intergenic transcription, and intergenic histone modification are not sufficient for transcription or modification of the target gene: these changes require initiation at the TATA box of the gene. The results suggest that intergenic and genic transcription complexes are independent and possibly differ from one another.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.