ArticleMolecular and cellular biology2007
A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
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- Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth.Nature communications · 2024Article
- RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks.Haematologica · 2021Article
- IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.The EMBO journal · 2020Article
- Subtype-specific regulatory network rewiring in acute myeloid leukemia.Nature genetics · 2019Article
- LncRNAs and miRs as epigenetic signatures in diabetic cardiac fibrosis: new advances and perspectives.Endocrine · 2018Review
- Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- T Cell Receptor and Cytokine Signaling Can Function at Different Stages to Establish and Maintain Transcriptional Memory and Enable T Helper Cell Differentiation.Frontiers in immunology · 2017Review
- Receptor Signaling Directs Global Recruitment of Pre-existing Transcription Factors to Inducible Elements.The Yale journal of biology and medicine · 2016Review
- Inducible chromatin priming is associated with the establishment of immunological memory in T cells.The EMBO journal · 2016Article
- Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood.BMC pulmonary medicine · 2015Article
- Nucleosomes are stably evicted from enhancers but not promoters upon induction of certain pro-inflammatory genes in mouse macrophages.PloS one · 2014Article
- Article
- The inducible tissue-specific expression of the human IL-3/GM-CSF locus is controlled by a complex array of developmentally regulated enhancers.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus.Molecular immunology · 2011Article
- Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2.The international journal of biochemistry & cell biology · 2011Article
- Article
- How do RNA sequence, DNA sequence, and chromatin properties regulate splicing?F1000 biology reports · 2010Article
- Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer.Nucleic acids research · 2010Article
- Transcription-dependent silencing of inducible convergent transgenes in transgenic mice.Epigenetics & chromatin · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated alternate mechanisms employed by enhancers to position and remodel nucleosomes and activate tissue-specific genes in divergent cell types. We demonstrated that the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene enhancer is modular and recruits different sets of transcription factors in T cells and myeloid cells. The enhancer recruited distinct inducible tissue-specific enhanceosome-like complexes and directed nucleosomes to different positions in these cell types. In undifferentiated T cells, the enhancer was activated by inducible binding of two NFAT/AP-1 complexes which disrupted two specifically positioned nucleosomes (N1 and N2). In myeloid cells, the enhancer was remodeled by GATA factors which constitutively displaced an upstream nucleosome (N0) and cooperated with inducible AP-1 elements to activate transcription. In mast cells, which express both GATA-2 and NFAT, these two pathways combined to activate the enhancer and generate high-level gene expression. At least 5 kb of the GM-CSF locus was organized as an array of nucleosomes with fixed positions, but the enhancer adopted different nucleosome positions in T cells and mast cells. Furthermore, nucleosomes located between the enhancer and promoter were mobilized upon activation in an enhancer-dependent manner. These studies reveal that distinct tissue-specific mechanisms can be used either alternately or in combination to activate the same enhancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.