ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 129 citations in OpenAlex.
- Amphiregulin promotes hair regeneration of skin-derived precursors via the PI3K and MAPK pathways.Cell proliferation · 2021Article
- On the road again: Establishment and maintenance of stemness in the neural crest from embryo to adulthood.Stem cells (Dayton, Ohio) · 2021Review
- BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons.International journal of molecular sciences · 2020Article
- In Vitro Differentiation of Human Skin-Derived Cells into Functional Sensory Neurons-Like.Cells · 2020Article
- Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?Stem cells translational medicine · 2020Article
- Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential.Cell death and differentiation · 2019Article
- CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties.PLoS genetics · 2019Article
- Isolation, Characterization, and Safety Evaluation of Human Skin-Derived Precursors from an Adherent Monolayer Culture System.Stem cells international · 2019Article
- Sonic hedgehog signalling regulates the self-renewal and proliferation of skin-derived precursor cells in mice.Cell proliferation · 2018Article
- Dental Pulp Stem Cells - Exploration in a Novel Animal Model: the Tasmanian Devil (Sarcophilus harrisii).Stem cell reviews and reports · 2018Review
- The Biological Role of NestinFrontiers in cell and developmental biology · 2018Review
- The Human Skin-Derived Precursors for Regenerative Medicine: Current State, Challenges, and Perspectives.Stem cells international · 2018Review
- Therapy of corneal endothelial dysfunction with corneal endothelial cell-like cells derived from skin-derived precursors.Scientific reports · 2017Article
- Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration.Stem cells translational medicine · 2017Article
- Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues.PloS one · 2017Article
- Skin-Derived Precursors against UVB-Induced Apoptosis via Bcl-2 and Nrf2 Upregulation.BioMed research international · 2016Article
- Enrichment of skin-derived neural precursor cells from dermal cell populations by altering culture conditions.Stem cell investigation · 2016Article
- Oriented cell division: new roles in guiding skin wound repair and regeneration.Bioscience reports · 2015Review
- Concise Review: Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine.Stem cells translational medicine · 2015Review
- Exogenous Nkx2.5- or GATA-4-transfected rabbit bone marrow mesenchymal stem cells and myocardial cell co-culture on the treatment of myocardial infarction in rabbits.Molecular medicine reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously made the surprising finding that cultures of multipotent precursors can be grown from the dermis of neonatal and adult mammalian skin. These skin-derived precursors (SKPs) display multi-lineage differentiation potential, producing both neural and mesodermal progeny in vitro, and are an apparently novel precursor cell type that is distinct from other known precursors within the skin. In this review, we begin by placing these findings within the context of the rapidly evolving stem cell field. We then describe our recent efforts focused on understanding the developmental biology of SKPs, discussing the idea that SKPs are neural crest-related precursors that (i) migrate into the skin during embryogenesis, (ii) persist within a specific dermal niche, and (iii) play a key role in the normal physiology, and potentially pathology, of the skin. We conclude by highlighting some of the therapeutic implications and unresolved questions raised by these studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.