ArticleTheoretical biology & medical modelling2007
Immunostimulation and immunoinhibition of premalignant lesions.
Article in Theoretical biology & medical modelling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation.Bulletin of mathematical biology · 2017Article
- A new kink in an old theory of carcinogenesis.Theoretical biology & medical modelling · 2013Article
- Immunoediting: evidence of the multifaceted role of the immune system in self-metastatic tumor growth.Theoretical biology & medical modelling · 2012Article
- Biphasic effect of a primary tumor on the growth of secondary tumor implants.Journal of cancer research and clinical oncology · 2010Article
- Anti-inflammatory pretreatment enables an efficient dendritic cell-based immunotherapy against established tumors.Cancer immunology, immunotherapy : CII · 2008Article
- Therapeutic anti-tumor vaccines: from tumor inhibition to enhancement.Clinical medicine. Oncology · 2008Article
- Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?Theoretical biology & medical modelling · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. HYPOTHESIS: A tumor-stimulatory immune response may be essential for survival of a neoplasm in vivo and for the biological progression from a premalignant lesion to a malignancy. Neither a positive nor a negative correlation between the magnitude of an immune-cell infiltrate and a cancer's prognosis can reveal whether the infiltrate was stimulating or inhibiting to the tumor's growth unless the position on the nonlinear curve that relates tumor growth to the magnitude of the immune reaction is known. DISCUSSION: This hypothesis is discussed in relation to the development of human malignant melanomas and colorectal cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.