ArticleDer Pathologe2007
[Intestinal neuronal dysplasia type B: how do we understand it today?].
Article in Der Pathologe, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Interstitial cells of Cajal: clinical relevance in pediatric gastrointestinal motility disorders.Pediatric surgery international · 2023Review
- Advances in understanding functional variations in the Hirschsprung disease spectrum (variant Hirschsprung disease).Pediatric surgery international · 2017Review
- Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Classification and diagnostic criteria of variants of Hirschsprung's disease.Pediatric surgery international · 2013Review
- [Twenty years diagnostic competence center for Hirschsprung's disease in Basel].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2010Article
- Anorectal manometry with reference to operative rectal biopsy for the diagnosis/exclusion of Hirschprung's disease in children under 1 year of age.International journal of colorectal disease · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Intestinal neuronal dysplasia type B (IND B) is currently considered to be a subtle malformation of the submucosal plexus, leading to an increased proportion of over-sized ganglia and potentially accompanied by a mild, chronic gastrointestinal motility disturbance. The diagnosis of IND B is morphologically based and involves the demonstration of an increased proportion of giant ganglia in the submucous plexus related to the patient's age. Giant ganglia are physiologically frequent in the neonatal period. Therefore, IND B should not be diagnosed prior to 1 year of age. Morphological features of IND B may occur as an isolated finding or may be observed proximal to an aganglionic segment. IND B and constipation may resolve spontaneously up to the age of 4 years. Treatment of IND B is usually conservative, surgical resection is currently deemed necessary only in a minority of patients. The pathogenesis of IND B is still incompletely understood and the etiology unknown. Future research on the basis of standardized diagnostic conditions is expected to result in a better understanding of this disease, and to reveal the cause of aberrant ganglion development.
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