ReviewWorld journal of gastroenterology2007
Physiological and clinical significance of enterochromaffin-like cell activation in the regulation of gastric acid secretion.
Review in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Proton pump inhibitors and the risk of gastric cancer: a systematic review, evidence synthesis and life course epidemiology perspective.BMJ open gastroenterology · 2025Pooled it
- Use of Antihistamine Drugs in Colitis: A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Effects of Medication Period and Gastrin Levels on Endoscopic Gastric Mucosal Changes in Long-Term Proton Pump Inhibitor Users.Diagnostics (Basel, Switzerland) · 2024Article
- The Impact of Sex on the Response to Proton Pump Inhibitor Treatment.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Intestinal Enteroendocrine Cells: Present and Future Druggable Targets.International journal of molecular sciences · 2023Review
- Mucosal distribution of somatostatin-secreting gastric Delta cells in children with gastrointestinal reflux diseases.Frontiers in pediatrics · 2023Article
- The expression of RIPK3 is associated with cell turnover of gastric mucosa in the mouse and human stomach.Journal of molecular histology · 2021Article
- Analysis of Somatostatin-Secreting Gastric Delta Cells according to Upper Abdominal Symptoms andPediatric gastroenterology, hepatology & nutrition · 2020Article
- Problems Associated with Deprescribing of Proton Pump Inhibitors.International journal of molecular sciences · 2019Review
- An unusual case of proton pump inhibitor induced hyperchromograninemia.Journal of community hospital internal medicine perspectives · 2019Article
- The expression of non-mast histamine in tumor associated microvessels in human colorectal cancers.Pathology oncology research : POR · 2013Article
- The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Withdrawing PPI therapy after healing esophagitis does not worsen symptoms or cause persistent hypergastrinemia: analysis of dexlansoprazole MR clinical trial data.The American journal of gastroenterology · 2011Article
- Up-regulation of histidine decarboxylase expression and histamine content in B16F10 murine melanoma cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Esomeprazole-induced hyperchromograninemia in the absence of concomitant hypergastrinemia.Nature reviews. Gastroenterology & hepatology · 2010Article
- Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight.Peptides · 2010Review
- Acid peptic diseases: pharmacological approach to treatment.Expert review of clinical pharmacology · 2009Article
- Hormonal regulation of gastric acid secretion.Current gastroenterology reports · 2008Review
- Progress in developing cholecystokinin (CCK)/gastrin receptor ligands that have therapeutic potential.Current opinion in pharmacology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric acid plays an important role in digesting food (especially protein), iron absorption, and destroying swallowed micro-organisms. H+ is secreted by the oxyntic parietal cells and its secretion is regulated by endocrine, neurocrine and paracrine mechanisms. Gastrin released from the antral G cell is the principal physiological stimulus of gastric acid secretion. Activation of the enterochromaffin-like (ECL) cell is accepted as the main source of histamine participating in the regulation of acid secretion and is functionally and trophically controlled by gastrin, which is mediated by gastrin/CCK-2 receptors expressed on the ECL cell. However, long-term hypergastrinemia will induce ECL cell hyperplasia and probably carcinoids. Clinically, potent inhibitors of acid secretion have been prescribed widely to patients with acid-related disorders. Long-term potent acid inhibition evokes a marked increase in plasma gastrin levels, leading to enlargement of oxyntic mucosa with ECL cell hyperplasia. Accordingly, the induction of ECL cell hyperplasia and carcinoids remains a topic of considerable concern, especially in long-term use. In addition, the activation of ECL cells also induces another clinical concern, i.e., rebound acid hypersecretion after acid inhibition. Recent experimental and clinical findings indicate that the activation of ECL cells plays a critical role both physiologically and clinically in the regulation of gastric acid secretion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.