ArticleGenetics2007
A balance between two nuclear localization sequences and a nuclear export sequence governs extradenticle subcellular localization.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- HOX and MEINOX in cellular plasticity, fibrosis, and cancer.World journal of stem cells · 2025Review
- Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression.Diagnostics (Basel, Switzerland) · 2023Article
- Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases.International journal of molecular sciences · 2023Article
- Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer.Cell death & disease · 2022Article
- A Computer-Based Methodology to Design Non-Standard Peptides Potentially Able to Prevent HOX-PBX1-Associated Cancer Diseases.International journal of molecular sciences · 2021Article
- Amino acid homorepeats in proteins.Nature reviews. Chemistry · 2020Review
- CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.PLoS biology · 2019Article
- Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida.BMC biology · 2018Article
- Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins.Nature structural & molecular biology · 2017Article
- Targeting HOX/PBX dimers in cancer.Oncotarget · 2017Review
- Alanine Expansions Associated with Congenital Central Hypoventilation Syndrome Impair PHOX2B Homeodomain-mediated Dimerization and Nuclear Import.The Journal of biological chemistry · 2016Article
- The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal.Developmental neurobiology · 2015Article
- The TALE face of Hox proteins in animal evolution.Frontiers in genetics · 2015Article
- Homothorax and Extradenticle alter the transcription factor network in Drosophila ommatidia at the dorsal rim of the retina.Development (Cambridge, England) · 2014Article
- Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells.Biology open · 2013Article
- Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning.PLoS genetics · 2013Article
- A glimpse into dorso-ventral patterning of the Drosophila eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
- Variable motif utilization in homeotic selector (Hox)-cofactor complex formation controls specificity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Competition for cofactor-dependent DNA binding underlies Hox phenotypic suppression.Genes & development · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
During animal development, transcription factor activities are modulated by several means, including subcellular localization. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax (Hth). These observations raise the question of whether dimerization with Hth simply induces Exd's nuclear localization or, alternatively, if Hth is also necessary for Exd activity. To address this question, we analyzed the nuclear transport signals in Exd, including a divergent nuclear export signal (NES) and two nuclear localization signals (NLSs). We show that, although these signals are weak compared to canonical signals, they balance each other in Exd. We also provide evidence that Exd contains an NLS mask that contributes to its cytoplasmic localization. With these signals characterized, we generated forms of Exd that are nuclear localized in the absence of Hth. Surprisingly, although these Exd forms are functional, they do not phenocopy Hth overexpression. These findings suggest that Hth is required for Exd activity, not simply for inducing its nuclear localization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.