ArticleBiophysical journal2007
Further evidence for the absence of polyproline II stretch in the XAO peptide.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Proline, a unique amino acid whose polymer, polyproline II helix, and its analogues are involved in many biological processes: a review.Amino acids · 2024Review
- Exploring Nearest Neighbor Interactions and Their Influence on the Gibbs Energy Landscape of Unfolded Proteins and Peptides.International journal of molecular sciences · 2022Review
- Glycine in Water Favors the Polyproline II State.Biomolecules · 2020Article
- Unravelling the effect ofChemical science · 2020Article
- Exploring Peptide⁻Solvent Interactions: A Computational Study.Molecules (Basel, Switzerland) · 2018Article
- Article
- Insights into Unfolded Proteins from the Intrinsic ϕ/ψ Propensities of the AAXAA Host-Guest Series.Biophysical journal · 2016Article
- Sodium dodecyl sulfate monomers induce XAO peptide polyproline II to α-helix transition.The journal of physical chemistry. B · 2014Article
- Local order in the unfolded state: conformational biases and nearest neighbor interactions.Biomolecules · 2014Review
- Conformational dissection of a viral intrinsically disordered domain involved in cellular transformation.PloS one · 2013Article
- Influence of the Length of the Alanine Spacer on the Acidic-Basic Properties of the Ac-Lys-(Ala)(n)-Lys-NH(2) Peptides (n = 0, 1, 2, …, 5).Journal of solution chemistry · 2012Article
- Conformational distributions of denatured and unstructured proteins are similar to those of 20 × 20 blocked dipeptides.Journal of biomolecular NMR · 2012Article
- A statistical analysis of the PPII propensity of amino acid guests in proline-rich peptides.Biophysical journal · 2011Article
- UV resonance Raman investigation of the conformations and lowest energy allowed electronic excited states of tri- and tetraalanine: charge transfer transitions.The journal of physical chemistry. B · 2010Article
- The relationship between water bridges and the polyproline II conformation: a large-scale analysis of molecular dynamics simulations and crystal structures.Protein engineering, design & selection : PEDS · 2010Article
- Characterizing aqueous solution conformations of a peptide backbone using Raman optical activity computations.Biophysical journal · 2008Article
- UV resonance raman investigation of electronic transitions in alpha-helical and polyproline II-like conformations.The journal of physical chemistry. B · 2008Article
- Acidic-basic properties of three alanine-based peptides containing acidic and basic side chains: comparison between theory and experiment.Biopolymers · 2008Article
- Studying the structural properties of polyalanine and polyglutamine peptides.Journal of molecular modeling · 2007Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
It has been suggested that the alanine-based peptide with sequence Ac-XX-[A](7)-OO-NH(2), termed XAO where X denotes diaminobutyric acid and O denotes ornithine, exists in a predominantly polyproline-helix (P(II)) conformation in aqueous solution. In our recent work, we demonstrated that this "polyproline conformation" should be regarded as a set of local conformational states rather than as the overall conformation of the molecule. In this work, we present further evidence to support this statement. Differential scanning calorimetry measurements showed only a very small peak in the heat capacity of an aqueous solution of XAO at 57 degrees C, whereas the suggested transition to the P(II) structure should occur at approximately 30 degrees C. We also demonstrate that the temperature dependence of the (3)J(HNHalpha) coupling constants of the alanine residues can be explained qualitatively in terms of Boltzmann averaging over all local conformational states; therefore, this temperature dependence proves that a conformational transition does not occur. Canonical MD simulations with the solvent represented by the generalized Born model, and with time-averaged NMR-derived restraints, demonstrate the presence of an ensemble of structures with a substantial amount of local P(II) conformational states but not with an overall P(II) conformation.
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