ArticleEukaryotic cell2007
Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 126 citations in OpenAlex.
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- Context-dependent reprogramming ofFrontiers in microbiology · 2026Article
- Molecular Determinants Involved in Candida albicans Biofilm Formation and Regulation.Molecular biotechnology · 2024Review
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- Typing ofPathogens (Basel, Switzerland) · 2023Article
- Antifungal Properties of Biogenic Selenium Nanoparticles Functionalized with Nystatin for the Inhibition ofMolecules (Basel, Switzerland) · 2023Article
- Constitutive ALS3 expression in Candida albicans enhances adhesion and biofilm formation of efg1, but not cph1 mutant strains.PloS one · 2023Article
- Hydroquinones Including Tetrachlorohydroquinone Inhibit Candida albicans Biofilm Formation by Repressing Hyphae-Related Genes.Microbiology spectrum · 2022Article
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- Ozone ultrafine bubble water inhibits the early formation of Candida albicans biofilms.PloS one · 2021Article
- On Commensalism ofJournal of fungi (Basel, Switzerland) · 2020Review
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- Investigating Common Pathogenic Mechanisms betweenToxins · 2019Article
- Influence of ZnO nanoparticles onIranian journal of microbiology · 2018Article
- Adhesins of Yeasts: Protein Structure and Interactions.Journal of fungi (Basel, Switzerland) · 2018Review
- Antigen I/II mediates interactions between Streptococcus mutans and Candida albicans.Molecular oral microbiology · 2018Article
- Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Candida albicans expresses specific virulence traits that promote disease establishment and progression. These traits include morphological transitions between yeast and hyphal growth forms that are thought to contribute to dissemination and invasion and cell surface adhesins that promote attachment to the host. Here, we describe the regulation of the adhesin gene ALS3, which is expressed specifically during hyphal development in C. albicans. Using a combination of reporter constructs and regulatory mutants, we show that this regulation is mediated by multiple factors at the transcriptional level. The analysis of ALS3 promoter deletions revealed that this promoter contains two activation regions: one is essential for activation during hyphal development, while the second increases the amplitude of this activation. Further deletion analyses using the Renilla reniformis luciferase reporter delineate the essential activation region between positions -471 and -321 of the promoter. Further 5' or 3' deletions block activation. ALS3 transcription is repressed mainly by Nrg1 and Tup1, but Rfg1 contributes to this repression. Efg1, Tec1, and Bcr1 are essential for the transcriptional activation of ALS3, with Tec1 mediating its effects indirectly through Bcr1 rather than through the putative Tec1 sites in the ALS3 promoter. ALS3 transcription is not affected by Cph2, but Cph1 contributes to full ALS3 activation. The data suggest that multiple morphogenetic signaling pathways operate through the promoter of this adhesin gene to mediate its developmental regulation in this major fungal pathogen.
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