ArticleEukaryotic cell2007
Drosophila melanogaster Thor and response to Candida albicans infection.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- The utility ofFrontiers in immunology · 2024Review
- Interactions between innate immunity and insulin signaling affect resistance to infection in insects.Frontiers in immunology · 2023Review
- A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection.Disease models & mechanisms · 2022Article
- Functional conservation in genes and pathways linking ageing and immunity.Immunity & ageing : I & A · 2021Review
- EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection.Cell reports · 2019Article
- The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection.Cell reports · 2017Article
- Host translation at the nexus of infection and immunity.Cell host & microbe · 2012Review
- The Drosophila melanogaster host model.Journal of oral microbiology · 2012Article
- Recent Advances in the Use of Drosophila melanogaster as a Model to Study Immunopathogenesis of Medically Important Filamentous Fungi.International journal of microbiology · 2012Article
- Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans.PloS one · 2011Article
- Identification of methylmercury tolerance gene candidates in Drosophila.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides in Drosophila.The Journal of biological chemistry · 2009Article
- Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions.Infection and immunity · 2008Article
- Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.