SynthesisJournal of fluency disorders2007
Genetic studies of stuttering in a founder population.
Synthesis in Journal of fluency disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Nature and nurture in stuttering: a systematic review on the case of Moses.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Pooled it
- Linkage analysis of a large African family segregating stuttering suggests polygenic inheritance.Human genetics · 2013Trial
- Unraveling Stuttering Through a Multi-Omics Lens.Life (Basel, Switzerland) · 2025Article
- Population-based genetic effects for developmental stuttering.HGG advances · 2022Article
- Evaluation of recurrentAdvanced genetics (Hoboken, N.J.) · 2021Article
- The Pharmacologic Treatment of Stuttering and Its Neuropharmacologic Basis.Frontiers in neuroscience · 2020Review
- The Pathogenesis, Assessment and Treatment of Speech Fluency Disorders.Deutsches Arzteblatt international · 2017Article
- Genetic contributions to stuttering: the current evidence.Molecular genetics & genomic medicine · 2017Article
- Stuttering: Clinical and research update.Canadian family physician Medecin de famille canadien · 2016Review
- Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering.American journal of human genetics · 2015Article
- Characteristics of Fluency and Speech in Two Families With High Incidences of Stuttering.Journal of speech, language, and hearing research : JSLHR · 2015Article
- Relation of motor, linguistic and temperament factors in epidemiologic subtypes of persistent and recovered stuttering: Initial findings.Journal of fluency disorders · 2015Article
- Stuttering among children exposed to (family) high expressed emotion families.Annals of medical and health sciences research · 2013Article
- Epidemiology of stuttering: 21st century advances.Journal of fluency disorders · 2013Review
- A role for inherited metabolic deficits in persistent developmental stuttering.Molecular genetics and metabolism · 2012Review
- Stuttering: Genetic updates and a case report.Advanced biomedical research · 2012Article
- Genetic bases of stuttering: the state of the art, 2011.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2012Review
- Genetic approaches to understanding the causes of stuttering.Journal of neurodevelopmental disorders · 2011Article
- Using brain imaging to unravel the mysteries of stuttering.Cerebrum : the Dana forum on brain science · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledGenome-wide linkage and association analyses were conducted to identify genetic determinants of stuttering in a founder population in which 48 individuals affected with stuttering are connected in a single 232-person genealogy. A novel approach was devised to account for all necessary relationships to enable multipoint linkage analysis. Regions with nominal evidence for linkage were found on chromosomes 3 (P=0.013, 208.8 centiMorgans (cM)), 13 (P=0.012, 52.6 cM), and 15 (P=0.02, 100 cM). Regions with nominal evidence for association with stuttering that overlapped with a linkage signal are located on chromosomes 3 (P=0.0047, 195 cM), 9 (P=0.0067, 46.5 cM), and 13 (P=0.0055, 52.6 cM). We also conducted the first meta-analysis for stuttering using results from linkage studies in the Hutterites and The Illinois International Genetics of Stuttering Project and identified regions with nominal evidence for linkage on chromosomes 2 (P=0.013, 180-195 cM) and 5 (P=0.0051, 105-120 cM; P=0.015, 120-135 cM). None of the linkage signals detected in the Hutterite sample alone, or in the meta-analysis, meet genome-wide criteria for significance, although some of the stronger signals overlap linkage mapping signals previously reported for other speech and language disorders. EDUCATIONAL
objectivesAfter reading this article, the reader will be able to: (1) summarize information about the background of common disorders and methodology of genetic studies; (2) evaluate the role of genetics in stuttering; (3) discuss the value of using founder populations in genetic studies; (4) articulate the importance of combining several studies in a meta-analysis; (5) discuss the overlap of genetic signals identified in stuttering with other speech and language disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.