Evidence map›Paper›PMID 17276306›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2007

Prognostic value of SPECT myocardial perfusion imaging in patients with elevated cardiac troponin I levels and atypical clinical presentation.

Sharmila Dorbala, Robert P Giugliano, Giridhar Logsetty, Divya Vangala, Rakesh Mishra, Sharon Crugnale, David Yang, Marcelo F Di Carli

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Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. ISCHEMIA questions and MITNEC answers: Defining and standardizing clinical ischemic jeopardy with SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  2. Risk stratification with vasodilator stress SPECT myocardial perfusion imaging in patients with elevated cardiac biomarkers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  3. Observational
  4. Review
  5. Safety and feasibility of regadenoson use for suboptimal heart rate response during symptom-limited standard Bruce exercise stress test.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012
    Article
  6. Review
  7. Article
  8. The troponin conundrum: clarification through stress myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2007
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sharmila DorbalaDivision of Nuclear Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. sdorbala@partners.org
Robert P Giugliano
Giridhar Logsetty
Divya Vangala
Rakesh Mishra
Sharon Crugnale
David Yang
Marcelo F Di Carli
Brigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe determined the prognostic value of myocardial perfusion imaging (MPI) in patients with atypical clinical presentations and unexpected elevation of cardiac troponin I (cTnI) levels. METHODS AND

resultsIn 156 consecutive patients with atypical presentations for acute coronary syndromes (ACS) and elevated cTnI levels undergoing MPI within 30 days, rates of all-cause mortality (100% follow-up; median follow-up, 611 days) and 6-month cardiac death and nonfatal myocardial infarction (96% follow-up; median follow-up, 167 days) were determined. The mean age of the patients was 68 +/- 14 years. The majority of the study cohort (96%) was at low to intermediate clinical risk for ACS (Thrombolysis in Myocardial Infarction score for unstable angina/non-ST-segment elevation myocardial infarction <5). The overall event rate was high, with 45 deaths (28.8%). There were 13 cardiac deaths/nonfatal myocardial infarctions in 6 months (8.3%). A normal MPI result was associated with a high event-free survival rate, whereas an abnormal MPI result was associated with a 3-fold and 7-fold higher risk of all-cause mortality and 6-month cardiac events, respectively. An abnormal MPI result was an independent predictor of all-cause death.

conclusionsIn patients with cTnI elevation and a low to intermediate risk for ACS, a normal MPI result portends a good prognosis. Patients with abnormal MPI results have a higher 6-month cardiac event rate and a worse survival rate.

Indexed as

Tomography, Emission-Computed, Single-PhotonAgedAged, 80 and overAngina, UnstableBiomarkersExercise TestFemaleGated Blood-Pool ImagingHeartHumansMaleMiddle AgedMyocardial InfarctionPrognosisProspective StudiesRadiopharmaceuticalsBiomarkersRadiopharmaceuticalsTechnetium Tc 99m SestamibiTroponin I

Identifiers

PMID17276306
OpenAlexW1972201198

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.