ArticleMolecular and cellular neurosciences2007
E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner.
Article in Molecular and cellular neurosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- A novel binding pocket in the D2 domain of protein tyrosine phosphatase mu (PTPmu) guides AI screen to identify small molecules that modulate tumour cell adhesion, growth and migration.Journal of cellular and molecular medicine · 2023Article
- Analysis of Retinal Microstructure in Eyes with Dissociated Optic Nerve Fiber Layer (DONFL) Appearance following Idiopathic Macular Hole Surgery: An Optical Coherence Tomography Study.Journal of personalized medicine · 2023Article
- Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance.International journal of molecular sciences · 2021Review
- RIP at the Synapse and the Role of Intracellular Domains in Neurons.Neuromolecular medicine · 2020Review
- Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish.Life science alliance · 2019Article
- EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer Cells.Frontiers in genetics · 2019Article
- Identification of a novel antagonist of the ErbB1 receptor capable of inhibiting migration of human glioblastoma cells.Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Article
- Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration.Journal of cellular biochemistry · 2011Article
- Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin.Molecular and cellular neurosciences · 2010Article
- PTPmu suppresses glioma cell migration and dispersal.Neuro-oncology · 2009Article
- The effects of canine bone marrow stromal cells on neuritogenesis from dorsal root ganglion neurons in vitro.Veterinary research communications · 2009Article
- Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration.Cancer research · 2009Article
- BCCIP associates with the receptor protein tyrosine phosphatase PTPmu.Journal of cellular biochemistry · 2008Article
- Proteome profiling of embryo chick retina.Proteome science · 2008Article
- Receptor protein tyrosine phosphatases and cancer: new insights from structural biology.Cell adhesion & migrationReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
During development of the visual system, retinal ganglion cells (RGCs) require cell-cell adhesion molecules and extracellular matrix proteins for axon growth. In this study, we demonstrate that the classical cadherin, E-cadherin, is expressed in RGCs from E6 to E12 and promotes neurite outgrowth from all regions of the chick retina at E6, E8 and E10. E-cadherin is also expressed in the optic tectum. E-cadherin adhesion blocking antibodies specifically inhibit neurite outgrowth on an E-cadherin substrate. The receptor-type protein tyrosine phosphatase, PTPmu, associates with E-cadherin. In this manuscript, we demonstrate that antisense-mediated down-regulation of PTPmu, overexpression of catalytically inactive PTPmu and perturbation of endogenous PTPmu using a specific PTPmu inhibitor peptide results in a substantial reduction in neurite outgrowth on E-cadherin. Taken together, these findings demonstrate that E-cadherin is an important adhesion molecule for chick RGC neurite outgrowth and suggest that PTPmu expression and catalytic activity are required for outgrowth on an E-cadherin substrate.
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