ArticleDevelopmental biology2007
FGF-mediated induction of ciliary body tissue in the chick eye.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- The development and the genetic diseases of the ciliary body.Cell insight · 2024Review
- Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.Trends in genetics : TIG · 2023Review
- A single-cell transcriptomic atlas of the human ciliary body.Cellular and molecular life sciences : CMLS · 2022Article
- Phase transition specified by a binary code patterns the vertebrate eye cup.Science advances · 2021Article
- NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression.Cell reports · 2021Article
- The Role of FGF9 in the Production of Neural Retina and RPE in a Pluripotent Stem Cell Model of Early Human Retinal Development.American journal of ophthalmology · 2019Article
- Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation.Cell reports · 2018Article
- Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling.International journal of molecular sciences · 2018Review
- Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells.Molecular biology of the cell · 2015Article
- Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling.Neural development · 2014Article
- Article
- Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6.Development (Cambridge, England) · 2011Article
- Retinal and anterior eye compartments derive from a common progenitor pool in the avian optic cup.Molecular vision · 2011Article
- The expression of Wnt2b in the optic cup lip requires a border between the pigmented and nonpigmented epithelium.Molecular vision · 2010Article
- Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes.Development (Cambridge, England) · 2009Article
- Dominant inhibition of lens placode formation in mice.Developmental biology · 2008Article
- Wnt signaling in eye organogenesis.Organogenesis · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Upon morphogenesis, the simple neuroepithelium of the optic vesicle gives rise to four basic tissues in the vertebrate optic cup: pigmented epithelium, sensory neural retina, secretory ciliary body and muscular iris. Pigmented epithelium and neural retina are established through interactions with specific environments and signals: periocular mesenchyme/BMP specifies pigmented epithelium and surface ectoderm/FGF specifies neural retina. The anterior portions (iris and ciliary body) are specified through interactions with lens although the molecular mechanisms of induction have not been deciphered. As lens is a source of FGF, we examined whether this factor was involved in inducing ciliary body. We forced the pigmented epithelium of the embryonic chick eye to express FGF4. Infected cells and their immediate neighbors were transformed into neural retina. At a distance from the FGF signal, the tissue transitioned back into pigmented epithelium. Ciliary body tissue was found in the transitioning zone. The ectopic ciliary body was never in contact with the lens tissue. In order to assess the contribution of the lens on the specification of normal ciliary body, we created optic cups in which the lens had been removed while still pre-lens ectoderm. Ciliary body tissue was identified in the anterior portion of lens-less optic cups. We propose that the ciliary body may be specified at optic vesicle stages, at the same developmental stage when the neural retina and pigmented epithelium are specified and we present a model as to how this could be accomplished through overlapping BMP and FGF signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.