ArticleBiochemical and biophysical research communications2007
Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. fusion [corrected] inhibition.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- In Vitro Influenza A Virus-Inactivating Activity of HIDROXPathogens (Basel, Switzerland) · 2025Article
- Article
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- Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves fromPlants (Basel, Switzerland) · 2023Article
- Olive Pomace Phenolic Compounds: From an Agro-Industrial By-Product to a Promising Ocular Surface Protection for Dry Eye Disease.Journal of clinical medicine · 2022Article
- Oleuropein as a Potent Compound against Neurological Complications Linked with COVID-19: A Computational Biology Approach.Entropy (Basel, Switzerland) · 2022Article
- Natural Products for the Prevention and Treatment of Oral Mucositis-A Review.International journal of molecular sciences · 2022Review
- Nutraceutical Role of Polyphenols and Triterpenes Present in the Extracts of Fruits and Leaves ofMolecules (Basel, Switzerland) · 2022Review
- HIV-1 Integrase Inhibitory Effects of Major Compounds Present in CareVid™: An Anti-HIV Multi-Herbal Remedy.Life (Basel, Switzerland) · 2022Article
- Antifungal Evaluation and Molecular Docking Studies ofMolecules (Basel, Switzerland) · 2021Article
- Phytochemical Characterization ofViruses · 2021Article
- The SARS-CoV-2-Inactivating Activity of Hydroxytyrosol-Rich Aqueous Olive Pulp Extract (HIDROXViruses · 2021Article
- Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis.Acta bio-medica : Atenei Parmensis · 2020Observational
- Biomechanical properties enhancement of gamma radiation-sterilized cortical bone using antioxidants.Radiation and environmental biophysics · 2020Article
- Molecular Docking and Molecular Dynamics Aided Virtual Search of OliveNet™ Directory for Secoiridoids to Combat SARS-CoV-2 Infection and Associated Hyperinflammatory Responses.Frontiers in molecular biosciences · 2020Article
- Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health.Molecules (Basel, Switzerland) · 2019Review
- Hydroxyoleoside-type seco-iridoids from Symplocos cochinchinensis and their insulin mimetic activity.Scientific reports · 2019Article
- Hydroxytyrosol: Health Benefits and Use as Functional Ingredient in Meat.Medicines (Basel, Switzerland) · 2018Review
- Understanding the link between antimicrobial properties of dietary olive phenolics and bacterial ATP synthase.International journal of biological macromolecules · 2017Article
- Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity.AIDS (London, England) · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
We have identified oleuropein (Ole) and hydroxytyrosol (HT) as a unique class of HIV-1 inhibitors from olive leaf extracts effective against viral fusion and integration. We used molecular docking simulation to study the interactions of Ole and HT with viral targets. We find that Ole and HT bind to the conserved hydrophobic pocket on the surface of the HIV-gp41 fusion domain by hydrogen bonds with Q577 and hydrophobic interactions with I573, G572, and L568 on the gp41 N-terminal heptad repeat peptide N36, interfering with formation of the gp41 fusion-active core. To test and confirm modeling predications, we examined the effect of Ole and HT on HIV-1 fusion complex formation using native polyacrylamide gel electrophoresis and circular dichroism spectroscopy. Ole and HT exhibit dose-dependent inhibition on HIV-1 fusion core formation with EC(50)s of 66-58nM, with no detectable toxicity. Our findings on effects of HIV-1 integrase are reported in the subsequent article.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.