Evidence map›Paper›PMID 17274661›Full record

ArticleNano letters2007

Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity.

Tatjana Paunesku, Stefan Vogt, Barry Lai, Jörg Maser, Natasa Stojićević, Kenneth T Thurn, Clodia Osipo, Hong Liu, Daniel Legnini, Zhou Wang and 2 more

Abstract read
In one paragraph

Article in Nano letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Development of FeCancer nanotechnology · 2021
    Article
  5. Review
  6. Article
  7. Subcellular Performance of Nanoparticles in Cancer Therapy.International journal of nanomedicine · 2020
    Review
  8. Review
  9. Article
  10. IntracellularNano research · 2018
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Stimuli-responsive nanomaterials for therapeutic protein delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014
    Review
  17. Mitochondria-targeting particles.Nanomedicine (London, England) · 2014
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tatjana PauneskuDepartment of Radiation Oncology, Northwestern University, Chicago, Illinois 60611, USA.
Stefan Vogt
Barry Lai
Jörg Maser
Natasa Stojićević
Kenneth T Thurn
Clodia Osipo
Hong Liu
Daniel Legnini
Zhou Wang
Chung Lee
Gayle E Woloschak

Funding

TiO2 nanocomposites for Targeted Treatment and Imaging of Prostate cancerU54CA119341 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2005 to 2009
$19.9M
SPORE IN BREAST CANCERP50CA089018 · NCI · NORTHWESTERN UNIVERSITY · PI JORDAN, VIRGIL CRAIG · 2000 to 2004
$14.2M
Applications of TiO2-DNA nanocompositesR01EB002100 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLOSCHAK, GAYLE E. · 2005 to 2013
$2.5M
Application of TiO2-DNA nanocomposites to Cancer CellsR01CA107467 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLOSCHAK, GAYLE E. · 2004 to 2006
$960k
NCI NIH HHS CA107467NCI NIH HHS P50 CA089018NCI NIH HHS P50 CA89018NCI NIH HHS R01 CA107467NCI NIH HHS U54 CA119341NCI NIH HHS U54CA119341NIBIB NIH HHS EB002100NIBIB NIH HHS R01 EB002100
6 · The paper itself

Abstract

Deoxyribonucleic acid (DNA) oligonucleotides hybridize to matching DNA sequences in cells, as established in the literature, depending on active transcription of the target sequence and local molarity of the oligonucleotide. We investigated the intracellular distribution of nanoconjugates composed of DNA oligonucleotides attached to TiO2 nanoparticles, thus creating a locally increased concentration of the oligonucleotide. Two types of nanoconjugates, with oligonucleotides matching mitochondrial or nucleolar DNA, were specifically retained in mitochondria or nucleoli.

Indexed as

AnimalsBase SequenceCell LineCell NucleolusDNA, MitochondrialHumansMetal NanoparticlesMicroscopy, ElectronMicroscopy, FluorescenceMitochondriaNanotechnologyOligodeoxyribonucleotidesPC12 CellsRatsTitaniumDNA, MitochondrialOligodeoxyribonucleotidesTitaniumtitanium dioxide

Identifiers

PMID17274661
PMCPMC3651270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.