ArticleAmerican journal of human genetics2007
Efficient association mapping of quantitative trait loci with selective genotyping.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Genomic selection strategies to overcome genotype by environment interactions in biosecurity-based aquaculture breeding programs.Genetics, selection, evolution : GSE · 2025Article
- Genotyping both live and dead animals to improve post-weaning survival of pigs in breeding programs.Genetics, selection, evolution : GSE · 2024Article
- HostSeq: a Canadian whole genome sequencing and clinical data resource.BMC genomic data · 2023Article
- Comparison of mixed model based approaches for correcting for population substructure with application to extreme phenotype sampling.BMC genomics · 2022Article
- Ranking subjects based on paired compositional data with application to age-related hearing loss subtyping.Communications for statistical applications and methods · 2020Article
- Extreme sampling design in genetic association mapping of quantitative trait loci using balanced and unbalanced case-control samples.Scientific reports · 2019Article
- A Cautionary Note on the Effects of Population Stratification Under an Extreme Phenotype Sampling Design.Frontiers in genetics · 2019Article
- EPS-LASSO: test for high-dimensional regression under extreme phenotype sampling of continuous traits.Bioinformatics (Oxford, England) · 2018Article
- Two-phase outcome-dependent studies for failure times and testing for effects of expensive covariates.Lifetime data analysis · 2018Article
- Identification of QTL with large effect on seed weight in a selective population of soybean with genome-wide association and fixation index analyses.BMC genomics · 2017Article
- Elevated systemic glutamic acid level in the non-obese diabetic mouse is Idd linked and induces beta cell apoptosis.Immunology · 2017Article
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- Article
- Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling.Journal of the American Statistical Association · 2015Article
- Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach.European journal of human genetics : EJHG · 2015Article
- Application of quantile regression to recent genetic and -omic studies.Human genetics · 2014Review
- Quantitative trait analysis in sequencing studies under trait-dependent sampling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Identifying rare variants associated with complex traits via sequencing.Current protocols in human genetics · 2013Review
- Response inhibition and ADHD traits: correlates and heritability in a community sample.Journal of abnormal child psychology · 2013Article
- Three EST-SSR markers associated with QTL for the growth of the clam Meretrix meretrix revealed by selective genotyping.Marine biotechnology (New York, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Selective genotyping (i.e., genotyping only those individuals with extreme phenotypes) can greatly improve the power to detect and map quantitative trait loci in genetic association studies. Because selection depends on the phenotype, the resulting data cannot be properly analyzed by standard statistical methods. We provide appropriate likelihoods for assessing the effects of genotypes and haplotypes on quantitative traits under selective-genotyping designs. We demonstrate that the likelihood-based methods are highly effective in identifying causal variants and are substantially more powerful than existing methods.
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Registered trials
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