ArticleInternational journal of legal medicine2008
Complex variability of intron 40 of the von Willebrand factor (vWF) gene.
Article in International journal of legal medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- A Rapid, Reliable and Reproducible Protocol for DNA Degradation in Genetic Applications.Cells · 2025Article
- A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles.International journal of legal medicine · 2011Article
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7 authors.
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Abstract
Intron 40 of the von Willebrand factor (vWF) gene exhibits a highly variable region of about 0.65 kb, which contains 5 juxtaposed STRs. We sequenced 0.65 kb amplicons from 68 chromosomes and found 2 frequent indel polymorphisms and 5 SNPs. The 68 chromosomes investigated here presented a total of 47 different haplotypes. Regarding the SNP allele distribution in our sample, we arranged our results of the vWF intron 40 into a system of 3 haplotypes, i.e. haplotypes a, b and c. Our review may be valuable in further optimising vWF typing in forensic applications and in avoiding pitfalls. Further attempts to develop sophisticated techniques may soon enable haplotyping using autosomale STR clusters.
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