ArticleMolecular genetics and genomics : MGG2007
Abiotic-stress induces demethylation and transcriptional activation of a gene encoding a glycerophosphodiesterase-like protein in tobacco plants.
Article in Molecular genetics and genomics : MGG, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 328 citations in OpenAlex.
- Plant Responses to Heavy Metal Stress: Molecular Mechanisms, Transcriptomic Regulation, and Multi-Omics Integration in Crop Improvement.Plants (Basel, Switzerland) · 2026Review
- Genome-Wide DNA Methylation Analysis of the Toxicological Responses to Foliar Cerium Application in Soybean.Toxics · 2026Article
- Effects of High Lithium Concentrations on the Growth, Biomass, Mineral Accumulation, Oxidative Stress, Antioxidant and Gene Expression Response, and DNA Methylation in Sunflower Plants.Plants (Basel, Switzerland) · 2026Article
- Genotype-dependent DNA methylation patterns are negatively associated with allelic variation rather than heat-induced gene expression in two contrasting potato genotypes.The Plant journal : for cell and molecular biology · 2026Article
- The nicotinamide hypothesis revisited-plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione.FEBS letters · 2025Review
- Review
- DNA Methylation Changes Reflect Aluminum Stress in Triticale and Epigenetic Control of the Trait.International journal of molecular sciences · 2025Article
- Stress Increases Ecological Risk of Glufosinate-Resistant Transgene Located on Alien Chromosomes in Hybrids Between TransgenicPlants (Basel, Switzerland) · 2025Article
- Unveiling the role of epigenetic mechanisms and redox signaling in alleviating multiple abiotic stress in plants.Frontiers in plant science · 2024Review
- Editorial: Molecular mechanisms of metal toxicity and transcriptional/post-transcriptional regulation in plant model systems.Frontiers in plant science · 2024Article
- A multi-level approach reveals key physiological and molecular traits in the response of two rice genotypes subjected to water deficit at the reproductive stage.Plant-environment interactions (Hoboken, N.J.) · 2023Review
- Histone Deacetylase Inhibitor, Sodium Butyrate-Induced Metabolic Modulation inInternational journal of molecular sciences · 2023Article
- Epigenomics in stress tolerance of plants under the climate change.Molecular biology reports · 2023Review
- Drought stress memory in a germplasm of synthetic and common wheat: antioxidant system, physiological and morphological consequences.Scientific reports · 2023Article
- Progress of Research on the Physiology and Molecular Regulation of Sorghum Growth under Salt Stress by Gibberellin.International journal of molecular sciences · 2023Review
- Article
- Physiological, Biochemical, and Epigenetic Reaction of Maize (International journal of molecular sciences · 2023Article
- Beyond transcription factors: more regulatory layers affecting soybean gene expression under abiotic stress.Genetics and molecular biology · 2023Article
- Regulatory mechanism ofFrontiers in plant science · 2023Article
- Redox status of the plant cell determines epigenetic modifications under abiotic stress conditions and during developmental processes.Journal of advanced research · 2022Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the relationship between gene expression and DNA methylation, transcriptionally activated genes were screened in hypomethylated transgenic tobacco plants expressing an anti-DNA methyltransferase sequence. Among 16 genes initially identified, one clone was found to encode a glycerophosphodiesterase-like protein (NtGPDL), earlier reported to be responsive to aluminium stress. When detached leaves from wild type tobacco plants were treated with aluminium, NtGPDL transcripts were induced within 6 h, and corresponding genomic loci were demethylated at CCGG sites within 1 h. Direct bisulfite methylation mapping revealed that CG sites in coding regions were selectively demethylated, and that promoter regions were totally unmethylated regardless of the stress. Salt and low temperature treatments also induced similar demethylation patterns. Such effects could be attributable to oxidative stress, since reactive oxygen species generated by paraquat efficiently induced the same pattern of demethylation at coding regions. Pathogen infection induced neither transcripts nor genomic demethylation. These results suggested a close correlation between methylation and expression of NtGPDL upon abiotic stresses with a cause-effect relationship. Since DNA methylation is linked to histone modification, it is conceivable that demethylation at coding regions might induce alteration of chromatin structure, thereby enhancing transcription. We propose that environmental responses of plants are partly mediated through active alteration of the DNA methylation status.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.