ArticleEuropean biophysics journal : EBJ2007
Kinetic models for peptide-induced leakage from vesicles and cells.
Article in European biophysics journal : EBJ, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Echinocandins have an alternative mode of action on biomimetic membranes that is not directly related to the functioning of (1,3) beta-glucan synthase.Cell death discovery · 2026Article
- Complex electrostatic effects on the selectivity of membrane-permeabilizing cyclic lipopeptides.Biophysical journal · 2023Article
- Applications and evolution of melittin, the quintessential membrane active peptide.Biochemical pharmacology · 2021Review
- The amyloid-inhibiting NCAM-PrP peptide targets Aβ peptide aggregation in membrane-mimetic environments.iScience · 2021Article
- Revisiting the Interaction of Melittin with Phospholipid Bilayers: The Effects of Concentration and Ionic Strength.International journal of molecular sciences · 2020Article
- Mechanistic Landscape of Membrane-Permeabilizing Peptides.Chemical reviews · 2019Review
- Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents.Soft matter · 2015Article
- Fluctuations and the rate-limiting step of peptide-induced membrane leakage.Biophysical journal · 2010Article
- Melittin-lipid bilayer interactions and the role of cholesterol.Biophysical journal · 2008Article
- Selectivity in the mechanism of action of antimicrobial mastoparan peptide Polybia-MP1.European biophysics journal : EBJ · 2008Article
- Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
4 authors.
Funding
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Abstract
In this article analytical expressions for peptide-induced membrane leakage are presented. Two different models for time-dependent leakage have been developed. In the first, the leakage is assumed to be coupled by pores formed by the peptides. In the second model the peptide is assumed to induce a stress/perturbation in the membrane, and in order to reduce the stress, rearrangements in the membrane are induced. The leakage is coupled to these rearrangements, and when equilibrium is achieved no more leakage occurs. From the kinetic models simple fitting routines have been developed involving only two fitting parameters, and these have been used to fit experimental data for two prion protein-derived peptides as well as the honey bee toxin melittin in both vesicles and erythrocytes with good results. The fitted parameters provide both a quantitative and a qualitative basis for interpreting the experimental results. In addition a model for the peptide concentration-dependent leakage is presented, which was used to fit experimental data for leakage induced by the prion protein-derived peptides. The models presented in this article are compared with other models for peptide-induced membrane leakage.
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