ArticleThe Journal of clinical investigation2007
Primitive hematopoietic cells resist HIV-1 infection via p21.
Article in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 124 citations in OpenAlex.
- Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection.International journal of molecular sciences · 2023Article
- The Role of p53 in HIV Infection.Current HIV/AIDS reports · 2023Review
- Molecular dynamics of genome editing with CRISPR-Cas9 and rAAV6 virus in human HSPCs to treat sickle cell disease.Molecular therapy. Methods & clinical development · 2023Article
- Article
- Consequences of HIV infection in the bone marrow niche.Frontiers in immunology · 2023Review
- HIV UTR, LTR, and Epigenetic Immunity.Viruses · 2022Review
- Predicted Cellular Interactors of the Endogenous Retrovirus-K Integrase Enzyme.Microorganisms · 2021Article
- Increased expression of CDKN1A/p21 in HIV-1 controllers is correlated with upregulation of ZC3H12A/MCPIP1.Retrovirology · 2020Article
- Article
- Role of platelet-derived microparticles in transfer of the chemokine receptor CXCR4 to CXCR4-negative cells.Medical journal of the Islamic Republic of Iran · 2019Article
- HIV-1 Vpr and p21 restrict LINE-1 mobility.Nucleic acids research · 2018Article
- Article
- Inhibition of HIV early replication by the p53 and its downstream gene p21.Virology journal · 2018Article
- Prostaglandin EMolecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.Journal of the International AIDS Society · 2017Article
- Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.EMBO molecular medicine · 2017Article
- Underlying mechanisms of HIV-1 latency.Virus genes · 2017Review
- Current views on HIV-1 latency, persistence, and cure.Folia microbiologica · 2017Review
- Article
- HIV-1 Is Restricted prior to Integration of Viral DNA in Primary Cord-Derived Human CD34+ Cells.Journal of virology · 2015Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hematopoietic stem cells are resistant to HIV-1 infection. Here, we report a novel mechanism by which the cyclin-dependent kinase inhibitor (CKI) p21(Waf1/Cip1/Sdi1) (p21), a known regulator of stem cell pool size, restricts HIV-1 infection of primitive hematopoietic cells. Modifying p21 expression altered HIV-1 infection prior to changes in cell cycling and was selective for p21 since silencing the related CKIs, p27(Kip1) and p18(INK4C), had no effect on HIV-1. We show that p21 blocked viral infection by complexing with HIV-1 integrase and aborting chromosomal integration. A closely related lentivirus with a distinct integrase, SIVmac-251, and the other cell-intrinsic inhibitors of HIV-1, Trim5alpha, PML, Murr1, and IFN-alpha, were unaffected by p21. Therefore, p21 is an endogenous cellular component in stem cells that provides a unique molecular barrier to HIV-1 infection and may explain how these cells remain an uninfected "sanctuary" in HIV disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.