ReviewJournal of applied genetics2007
Methods of minimal residual disease (MRD) detection in childhood haematological malignancies.
Review in Journal of applied genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 24 citations in OpenAlex.
- Advances in liquid biopsy in neuroblastoma.Fundamental research · 2022Review
- Review
- Detection of relapse after hematopoietic stem cell transplantation in childhood by monitoring of WT1 expression and chimerism.Journal of cancer research and clinical oncology · 2015Article
- Testicular tissue cryopreservation and spermatogonial stem cell transplantation to restore fertility: from bench to bedside.Stem cell research & therapy · 2014Review
- Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions.Human reproduction (Oxford, England) · 2011Article
- New advances on the expansion and storage of human spermatogonial stem cells.Current opinion in urology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The appropriate management of haematological disorders must rely on a precise and long-term monitoring of the patient's response to chemotherapy and radiotherapy. Clinical data are not sufficient and that is why in the last decade it became the most important to improve the knowledge of haematological diseases on the basis of molecular techniques and molecular markers. The presence of residual malignant cells among normal cells is termed minimal residual disease (MRD). Nowadays a great progress has been made in the treatment of malignant diseases and in the development of reliable molecular techniques, which are characterised by high sensitivity (10-3- 10-6) and ability to distinguish between normal and malignant cells at diagnosis and during follow-up. Especially, MRD data based on quantitative analysis (RQ-PCR, RT-RQ-PCR) appear to be crucial for appropriate evaluation of treatment response in many haematological malignancies. Implementation of standardized approaches for MRD assessment into routine molecular diagnostics available in all oncohaematological centres should be regarded nowadays a crucial point in further MRD study development.
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Registered trials
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