ArticleThe Journal of physiology2007
Remodelling of action potential and intracellular calcium cycling dynamics during subacute myocardial infarction promotes ventricular arrhythmias in Langendorff-perfused rabbit hearts.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Cold storage of mouse hearts prior to cardiomyocyte isolation preserves electromechanical function, microstructure, and gene expression for 24 h.Basic research in cardiology · 2025Article
- The electrical restitution of the non-propagated cardiac ventricular action potential.Pflugers Archiv : European journal of physiology · 2024Review
- Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling.The Journal of general physiology · 2022Review
- Ventricular Arrhythmias in Ischemic Cardiomyopathy-New Avenues for Mechanism-Guided Treatment.Cells · 2021Review
- Beneficial Electrophysiological Effects of Rotigaptide Are Unable to Suppress Therapeutic Hypothermia-Provoked Ventricular Fibrillation in Failing Rabbit Hearts With Acute Ischemia-Reperfusion Injury.Frontiers in physiology · 2021Article
- Modeling the Electrophysiological Properties of the Infarct Border Zone.Frontiers in physiology · 2018Review
- Article
- Radionuclide imaging of cardiac sympathetic innervation in heart failure: unlocking untapped potential.Heart failure reviews · 2015Review
- Targeted antioxidant treatment decreases cardiac alternans associated with chronic myocardial infarction.Circulation. Arrhythmia and electrophysiology · 2015Article
- Effects of dantrolene on arrhythmogenicity in isolated regional ischemia-reperfusion rabbit hearts with or without pacing-induced heart failure.BioMed research international · 2015Article
- Article
- I -123 metaiodobenzylguanidine imaging for predicting ventricular arrhythmia in heart failure patients.Journal of biomedical research · 2013Review
- Apamin-sensitive calcium-activated potassium currents in rabbit ventricles with chronic myocardial infarction.Journal of cardiovascular electrophysiology · 2013Article
- The design and use of an optical mapping system for the study of intracardiac electrical signaling.Indian pacing and electrophysiology journal · 2012Article
- A novel, minimally invasive, segmental myocardial infarction with a clear healed infarct borderzone in rabbits.American journal of physiology. Heart and circulatory physiology · 2012Article
- Use of cardiac radionuclide imaging to identify patients at risk for arrhythmic sudden cardiac death.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Review
- Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers.Circulation · 2008Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
We hypothesize that remodelling of action potential and intracellular calcium (Ca(i)) dynamics in the peri-infarct zone contributes to ventricular arrhythmogenesis in the postmyocardial infarction setting. To test this hypothesis, we performed simultaneous optical mapping of Ca(i) and membrane potential (V(m)) in the left ventricle in 15 rabbit hearts with myocardial infarction for 1 week. Ventricular premature beats frequently originated from the peri-infarct zone, and 37% showed elevation of Ca(i) prior to V(m) depolarization, suggesting reverse excitation-contraction coupling as their aetiology. During electrically induced ventricular fibrillation, the highest dominant frequency was in the peri-infarct zone in 61 of 70 episodes. The site of highest dominant frequency had steeper action potential duration restitution and was more susceptible to pacing-induced Ca(i) alternans than sites remote from infarct. Wavebreaks during ventricular fibrillation tended to occur at sites of persistently elevated Ca(i). Infusion of propranolol flattened action potential duration restitution, reduced wavebreaks and converted ventricular fibrillation to ventricular tachycardia. We conclude that in the subacute phase of myocardial infarction, the peri-infarct zone exhibits regions with steep action potential duration restitution slope and unstable Ca(i) dynamics. These changes may promote ventricular extrasystoles and increase the incidence of wavebreaks during ventricular fibrillation. Whereas increased tissue heterogeneity after subacute myocardial infarction creates a highly arrhythmogenic substrate, dynamic action potential and Ca(i) cycling remodelling also contribute to the initiation and maintenance of ventricular fibrillation in this setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.