ArticleNucleic acids research2007
Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Proteomic Identification of Small-Subunit Ribosome Assembly Factors inJournal of proteome research · 2026Article
- Molecular recording of calcium signals via calcium-dependent proximity labeling.Nature chemical biology · 2024Article
- Ribosome biogenesis factors-from names to functions.The EMBO journal · 2023Review
- Human nucleolar protein SURF6/RRP14 participates in early steps of pre-rRNA processing.PloS one · 2023Article
- Rrp14 controls rRNA transcription via facilitating the translocation of Pol5 into the nucleolus.Cell cycle (Georgetown, Tex.) · 2022Article
- Validating RRP12 Expression and Its Prognostic Significance in HCC Based on Data Mining and Bioinformatics Methods.Frontiers in oncology · 2022Article
- A Higher Level of Expression of the Nucleolar Protein SURF6 in Human Normal Activated Lymphocytes and in Lymphocytes of Patients with Lymphoproliferative Disorders.Doklady. Biochemistry and biophysics · 2020Article
- Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms.Nature communications · 2018Article
- Involvement of the specific nucleolar protein SURF6 in regulation of proliferation and ribosome biogenesis in mouse NIH/3T3 fibroblasts.Cell cycle (Georgetown, Tex.) · 2017Article
- EWSR1 regulates mitosis by dynamically influencing microtubule acetylation.Cell cycle (Georgetown, Tex.) · 2016Article
- The nuclear basket mediates perinuclear mRNA scanning in budding yeast.The Journal of cell biology · 2015Article
- A pipeline for determining protein-protein interactions and proximities in the cellular milieu.Molecular & cellular proteomics : MCP · 2014Article
- Functional significance of the human nucleolar protein SURF6, the key member of the SURF6 protein family in eukaryotes.Doklady. Biochemistry and biophysics · 2014Article
- Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes.Molecular biology of the cell · 2013Article
- Ribosome biogenesis in the yeast Saccharomyces cerevisiae.Genetics · 2013Review
- Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication.Nucleic acids research · 2012Article
- Prediction of biological functions of Shewanella-like protein phosphatases (Shelphs) across different domains of life.Functional & integrative genomics · 2012Review
- Development of novel mouse hybridomas producing monoclonal antibodies specific to human and mouse nucleolar protein SURF-6.Hybridoma (2005) · 2012Article
- Pronounced and extensive microtubule defects in a Saccharomyces cerevisiae DIS3 mutant.Yeast (Chichester, England) · 2011Article
- Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Here we report that Rrp14p/Ykl082p is associated with pre-60S particles and to a lesser extent with earlier 90S pre-ribosomes. Depletion of Rrp14p inhibited pre-rRNA synthesis on both the 40S and 60S synthesis pathways. Synthesis of the 20S precursor to the 18S rRNA was largely blocked, as was maturation of the 27SB pre-rRNA to the 5.8S and 25S rRNAs. Unexpectedly, Rrp14p-depleted cells also showed apparently specific cell-cycle defects. Following release from synchronization in S phase, Rrp14p-depleted cells uniformly arrested in metaphase with short mitotic spindles that were frequently incorrectly aligned with the site of bud formation. In the absence of Bub2p, which is required for the spindle orientation checkpoint, this metaphase arrest was not seen in Rrp14p-depleted cells, which then arrested with multiple buds, several SPBs and binucleate mother cells. These data suggest that Rrp14p may play some role in cell polarity and/or spindle positioning, in addition to its function in ribosome synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.