ArticleNucleic acids research2007
DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Article
- Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair inGenes · 2022Article
- CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion.Nature communications · 2021Article
- The Role of Blm Helicase in Homologous Recombination, Gene Conversion Tract Length, and Recombination Between Diverged Sequences inGenetics · 2017Article
- RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.Biomarker research · 2016Article
- Characterization of the Caenorhabditis elegans HIM-6/BLM helicase: unwinding recombination intermediates.PloS one · 2014Article
- Essential functions of C terminus of Drosophila Topoisomerase IIIα in double holliday junction dissolution.The Journal of biological chemistry · 2012Article
- Unwinding and rewinding: double faces of helicase?Journal of nucleic acids · 2012Article
- Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.PloS one · 2012Article
- Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.Nature structural & molecular biology · 2010Article
- Article
- Promotion and regulation of homologous recombination by DNA helicases.Methods (San Diego, Calif.) · 2010Review
- An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.The EMBO journal · 2010Article
- Distinct roles of RECQ1 in the maintenance of genomic stability.DNA repair · 2010Review
- Article
- Article
- Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.The Journal of biological chemistry · 2009Article
- Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
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2 authors.
Funding
Abstract
Genetic analysis of the Drosophila Bloom's syndrome helicase homolog (mus309/DmBLM) indicates that DmBLM is required for the synthesis-dependent strand annealing (SDSA) pathway of homologous recombination. Here we report the first biochemical study of DmBLM. Recombinant, epitope-tagged DmBLM was expressed in Drosophila cell culture and highly purified protein was prepared from nuclear extracts. Purified DmBLM exists exclusively as a high molecular weight ( approximately 1.17 MDa) species, is a DNA-dependent ATPase, has 3'-->5' DNA helicase activity, prefers forked substrate DNAs and anneals complementary DNAs. High-affinity DNA binding is ATP-dependent and low-affinity ATP-independent interactions contribute to forked substrate DNA binding and drive strand annealing. DmBLM combines DNA strand displacement with DNA strand annealing to catalyze the displacement of one DNA strand while annealing a second complementary DNA strand.
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