ArticleFertility and sterility2007
Influence of hysterectomy on long-term fracture risk.
Article in Fertility and sterility, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Risk of osteoporosis and fracture after hysterectomies without oophorectomies: a systematic review and pooled analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- The Gut Microbiota: a Novel Player in the Pathogenesis of Uterine Fibroids.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Risk of Fracture After Bilateral Oophorectomy.JBMR plus · 2023Article
- Relationship between myomectomy and risk of osteoporosis or fracture: A population-based cohort study.PloS one · 2023Article
- Multiparametric MR evaluation of uterine leiomyosarcoma and STUMP versus leiomyoma in symptomatic women planned for high frequency focussed ultrasound: accuracy of imaging parameters and interobserver agreement for identification of malignancy.The British journal of radiology · 2021Article
- Post-surgery cholecystectomy, hepatectomy, and pancreatectomy patients increase the risk of osteoporotic vertebral fracture.Journal of bone and mineral metabolism · 2021Article
- Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies.International journal of molecular sciences · 2020Review
- Long-term risk of de novo mental health conditions after hysterectomy with ovarian conservation: a cohort study.Menopause (New York, N.Y.) · 2020Article
- Hysterectomies are associated with an increased risk of osteoporosis and bone fracture: A population-based cohort study.PloS one · 2020Article
- Cardiovascular and metabolic morbidity after hysterectomy with ovarian conservation: a cohort study.Menopause (New York, N.Y.) · 2018Article
- Comparative Effectiveness of Uterine Leiomyoma Procedures Using a Large Insurance Claims Database.Obstetrics and gynecology · 2017Article
- Menopause, Reproductive Life, Hormone Replacement Therapy, and Bone Phenotype at Age 60-64 Years: A British Birth Cohort.The Journal of clinical endocrinology and metabolism · 2016Article
- Cardiovascular risk factors and diseases in women undergoing hysterectomy with ovarian conservation.Menopause (New York, N.Y.) · 2016Article
- Reassessing hysterectomy.Minnesota medicine · 2012Article
- Increased incident hip fractures in postmenopausal women with moderate to severe pelvic organ prolapse.Menopause (New York, N.Y.) · 2011Article
- FRAX assessment of osteoporotic fracture probability in Switzerland.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Bone fractures and incident epithelial ovarian cancer in a prospective cohort study.Journal of women's health (2002) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess long-term fracture risk after hysterectomy, with or without oophorectomy.
designPopulation-based, cohort study.
settingOlmsted County, Minnesota. PATIENT(S): Women residing in Olmsted County (n = 9,258) who underwent hysterectomy in 1965-2002, compared to an equal number of age- and sex-matched community controls. INTERVENTION(S): Observational study of the effect of hysterectomy for various indications on subsequent fractures. MAIN OUTCOME MEASURE(S): Fractures of any type, and at osteoporotic sites (e.g., hip, spine, or wrist) alone, as assessed by electronic review of inpatient and outpatient diagnoses in the community. RESULT(S): Compared with controls, there was a significant increase (hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.13-1.29) in overall fracture risk among the women with a hysterectomy, but osteoporotic fracture risk was not elevated (HR, 1.09; 95% CI, 0.98-1.22). Most hysterectomy indications were associated with fractures generally, although these were not often statistically significant. Only operations for a uterine prolapse were associated with osteoporotic fractures (HR, 1.33; 95% CI, 1.01-1.74). Oophorectomy was not an independent predictor of fracture risk (HR, 1.0; 95% CI, 0.98-1.15). CONCLUSION(S): Hysterectomy does not appear to pose much long-term risk for fractures, but the association of fractures with surgery for uterine prolapse deserves further attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.