Trial reportLipids2006
Long-chain n-3 polyunsaturated fatty acid incorporation into human atrium following fish oil supplementation.
Trial report in Lipids, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The effect of omega-3 polyunsaturated fatty acid intake on blood levels of omega-3s in people with chronic atherosclerotic disease: a systematic review.Nutrition reviews · 2023Pooled it
- The Antioxidant Effect of Dietary Bioactives Arises from the Interplay between the Physiology of the Host and the Gut Microbiota: Involvement of Short-Chain Fatty Acids.Antioxidants (Basel, Switzerland) · 2023Review
- Amazonian fruits with potential effects on COVID-19 by inflammaging modulation: A narrative review.Journal of food biochemistry · 2022Review
- Bioactive substances and potentiality of marine microalgae.Food science & nutrition · 2021Review
- Interaction of diet and the masou salmon Δ5-desaturase transgene on Δ6-desaturase and stearoyl-CoA desaturase gene expression and N-3 fatty acid level in common carp (Cyprinus carpio).Transgenic research · 2014Article
- Characterization of docosahexaenoic acid (DHA)-induced heme oxygenase-1 (HO-1) expression in human cancer cells: the importance of enhanced BTB and CNC homology 1 (Bach1) degradation.The Journal of nutritional biochemistry · 2014Article
- Investigation of the effects of a high fish diet on inflammatory cytokines, blood pressure, and lipids in healthy older Australians.Food & nutrition research · 2014Article
- Cardiac physiology and clinical efficacy of dietary fish oil clarified through cellular mechanisms of omega-3 polyunsaturated fatty acids.European journal of applied physiology · 2014Review
- The role of long-chained marine N-3 polyunsaturated Fatty acids in cardiovascular disease.Cardiology research and practice · 2012Article
- The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expression.Lipids · 2011Article
- Artificial rearing of infant mice leads to n-3 fatty acid deficiency in cardiac, neural and peripheral tissues.Lipids · 2009Article
- Consumption of an n-3 polyunsaturated fatty acid-enriched dip modulates plasma lipid profile in subjects with diabetes type II.European journal of clinical nutrition · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated that long-chain n-3 PUFA (LCn-3PUFA) are beneficial in reducing the risk of cardiac arrhythmias. This study was conducted to determine the extent of incorporation of LCn-3PUFA into human atrium following supplementation with a fish oil concentrate high in LCn-3PUFA. Volunteers preparing for coronary bypass surgery were randomized either to the treatment group (n = 8), receiving 6 g/d of fish oil concentrate (4.4 g of LCn-3PUFA), or the placebo group (n = 9), receiving 6 g/d of olive oil for a minimum period of 6 wk. Blood samples were collected prior to commencement of treatment, and preoperatively before bypass surgery. Atrial biopsies were obtained during surgery. The plasma and atrium samples were analyzed by GC following trans-methylation to determine FA profile. Post-supplementation, the treatment group had significantly higher plasma levels of 20:5n-3, 22:5n-3, and 22:6n-3 than the placebo group. Analysis of the atrium total lipids revealed a significant increase in the proportion of 20:5n-3 following fish oil supplementation. There was no significant difference in the concentration of 22:5n-3 and 22:6n-3 in the atrium total lipids; however, an upward trend was observed in subjects receiving fish oil supplementation. In the phospholipid fraction of the atrium, both 20:5n-3 and 22:6n-3 increased, whereas 20:4n-6 levels decreased. This study demonstrates for the first time that short-term supplementation with fish oil concentrate results in significant incorporation of LCn-3PUFA with a concomitant depletion of the eicosanoid substrate (20:4n-6) in the human atrium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.