ArticleEcotoxicology (London, England)2007
Chironomids: suitable test organisms for risk assessment investigations on the potential endocrine disrupting properties of pesticides.
Article in Ecotoxicology (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 77 citations in OpenAlex.
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- Possible enzymatic mechanism underlying chemical tolerance and characteristics of tolerant population in Scapholeberis kingi.Environmental science and pollution research international · 2022Article
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- Lethal and sublethal effects of the saline stressor sodium chloride on Chironomus xanthus and Girardia tigrina.Environmental science and pollution research international · 2020Article
- Lethal and sub-lethal effects of cyproconazole on freshwater organisms: a case study with Chironomus riparius and Dugesia tigrina.Environmental science and pollution research international · 2018Article
- Endocrine disruption in aquatic systems: up-scaling research to address ecological consequences.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Article
- Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz.Ecotoxicology (London, England) · 2017Article
- Environmental quality assessment of reservoirs impacted by Hg from chlor-alkali technologies: case study of a recovery.Environmental science and pollution research international · 2016Article
- Article
- Low field-relevant tebufenozide concentrations affect reproduction in Chironomus riparius (Diptera: Chironomidae) in a long-term toxicity test.Environmental science and pollution research international · 2013Article
- Sediment organic tin contamination promotes impoverishment of non-biting midge species communities in the Archipelago Sea, S-W Finland.Ecotoxicology (London, England) · 2012Article
- Endocrine disruption in aquatic insects: a review.Ecotoxicology (London, England) · 2007Review
- Developing Test Guidelines on invertebrate development and reproduction for the assessment of chemicals, including potential endocrine active substances- the OECD perspective.Ecotoxicology (London, England) · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selecting an appropriate invertebrate assay has been a primary goal of national and international testing programs for endocrine disrupting chemicals. The available information on the endocrine system, its hormones and their modes of action in controlling physiological processes in invertebrates is limited and the selection of appropriate test species still presents a challenge. This paper outlines the development of a higher-tier full life cycle (FLC) test for pesticides with the non-biting midge Chironomus riparius (Insecta, Diptera, Chironomidae). As an insect, C. riparius represents the species' richest and ecologically one of the most important groups of invertebrates. In addition, the endocrine system of insects is one of the best studied among the invertebrates. Acute and chronic tests with Chironomus spp. are commonly used for testing and risk assessment of agrochemicals. A chironomid FLC test protocol has been developed and its suitability investigated in an inter-laboratory comparison. The protocol used is based on existing OECD and US-EPA test methods. To verify the suitability of the test to generate endpoints that encompass adverse effects on the arthropod endocrine system, a juvenile hormone analog was selected as positive control substance. Results have demonstrated that the proposed chironomid FLC can be performed in separate laboratories and that the selected arthropod juvenile hormone mimic causes effects. However, the observed toxicity is not proof of an endocrine disruptive mechanism and could equally be evoked by other compounds. Contrary to a screening assay, which aims at revealing a substance's mode-of-action, the FLC test generates robust, population-relevant endpoints that can be used in the risk assessment of agrochemicals. Since the initial results presented in this paper are encouraging we propose to complete the validation of this assay under OECD with high priority.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.