Trial reportEuropean journal of clinical nutrition2007
The duration of enzyme induction in orocaecal transit time measurements.
Trial report in European journal of clinical nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- The effect of pre- and probiotics on the colonic ammonia metabolism in humans as measured by lactose-[¹⁵N₂]ureide.European journal of clinical nutrition · 2010Trial
- The metabolic fate of doubly labelled lactose-[13C, 15N]ureide after pre-dosing with different ureides.European journal of clinical nutrition · 2010Trial
- Measurement of Oro-Cecal Transit Time in LPS-Treated Pigs Fed High and Low Fiber Diets Using the Lactose-Journal of agricultural and food chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this study, the duration of enzyme induction provoked by unlabelled lactose ureide (LU) in orocaecal transit time (OCTT) measurements with lactose-[(13)C]ureide ((13)C-LU) was evaluated.
designExperimental study.
settingUniversity of Rostock, Children's Hospital, Research Laboratory. SUBJECTS: Fifteen healthy adults aged 19-54 years.
interventionOne-half gram of (13)C-LU was administered together with a continental breakfast. After 1 week, the test was repeated after pre-dosing of 5 x 100 mg LU on the day before the study began. The (13)C-LU ingestion was repeated under identical conditions but without pre-dosing 1 and 3 weeks after pre-dosing. Expired air samples were taken over 14 h. (13)CO(2)-enrichment was measured by isotope ratio mass spectrometry (SerCon, Crewe, UK). The OCTT was calculated from the interval between (13)C-LU administration and the detection of a significant and sustained (13)C-rise of 2 delta over baseline in breath.
resultsWithout pre-dosing, an OCTT of 419+/-82 min was measured. The pre-dosing resulted in higher (13)C-enrichments and caused a significant OCTT shortening of 311+/-99 min (P=0.028). One and 3 weeks after pre-dosing, the measured OCTT again increased to 404+/-124 and 379+/-103 min, respectively.
conclusionsPre-dosing with LU before pulse labelling with (13)C-LU led to an induction of enzyme activity and resulted in a definitive estimation of the OCTT when using a threshold of 2 delta over baseline. After 1 and 3 weeks, respectively, the OCTT was no longer significantly different to those without pre-dosing, indicating the disappearance of enzyme induction. Therefore, a pre-dosing with LU on the day before (13)C-LU ingestion is essential for OCTT measurements.
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