Evidence map›Paper›PMID 17268410›Full record

Trial reportEuropean journal of clinical nutrition2007

A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans.

S Kolida, D Meyer, G R Gibson

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04543877 (WHNRC), which is not on this map. Cited by 69 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 5 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04543877 early_phase1completednot on this mapstarted 2022, after this paper: background citation

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2022 to 2025Enrolled60ConditionsInflammation, Vaccine, Intestinal Permeability, Typhoid FeverArmsInulin, Maltodextrin, Ty21a Typhoid Fever Vaccine
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 177 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

S KolidaDepartment of Food Biosciences, Food Microbial Sciences Unit, The University of Reading, Reading, UK. s.kolida@reading.ac.uk
D Meyer
G R Gibson
University of Reading · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the bifidogenic efficacy of two inulin doses in healthy human adults.

designA double-blind, placebo-controlled, crossover human study.

settingFood Microbial Sciences Unit, The University of Reading, Reading, UK. SUBJECTS: Thirty healthy volunteers, 15 men, 15 women (age range 19-35).

interventionsSubjects consumed a chocolate drink containing placebo (maltodextrin, 8 g/day), 5 g/day inulin and 8 g/day inulin for a 2-week treatment period. Each treatment was followed by a 1-week washout at the end of which volunteers progressed to the next treatment. Faecal samples were obtained at the start of the study (baseline) and at the end of each treatment and washout period. Fluorescent in situ hybridization was used to monitor populations of Bifidobacterium genus, Bacteroides - Prevotella, Lactobacillus - Enterococcus and Clostridium perfringens - histolyticum subgroup.

resultsBifidobacterial levels increased significantly upon ingestion of both the low (9.78+/-0.29 log(10) cells/g faeces, P<0.05) and the high inulin dose (9.79+/-0.38 log(10) cells/g faeces, P=0.05) compared to placebo (9.64+/-0.23 log(10) cells/g faeces).

conclusionsBoth inulin doses exhibited a bifidogenic effect but a higher volunteer percentage responded to the high dose. A dose response effect was not observed but the magnitude of increase in bifidobacteria levels depended on their initial numbers. The higher the initial concentrations the smaller was the increase upon ingestion of the active treatments.

Indexed as

ProbioticsAdultBifidobacteriumColonColony Count, MicrobialCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFecesFemaleFermentationHumansIn Situ Hybridization, FluorescenceInulinMaleInulin

Identifiers

PMID17268410
OpenAlexW2116710945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.