ArticleGenome research2007
Large-scale identification of novel transcripts in the human genome.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Genome-wide characterization of intergenic polyadenylation sites redefines gene spaces in Arabidopsis thaliana.BMC genomics · 2015Article
- Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration.Developmental cell · 2013Article
- Human genetics and genomics a decade after the release of the draft sequence of the human genome.Human genomics · 2011Review
- Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns.Nucleic acids research · 2010Article
- Novel transcripts discovered by mining genomic DNA from defined regions of bovine chromosome 6.BMC genomics · 2009Article
- The antisense transcriptomes of human cells.Science (New York, N.Y.) · 2008Article
- Non-protein coding RNA biomarkers and differential expression in cancers: a review.Journal of experimental & clinical cancer research : CR · 2008Review
- Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE.BMC genomics · 2008Article
- The Songbird Neurogenomics (SoNG) Initiative: community-based tools and strategies for study of brain gene function and evolution.BMC genomics · 2008Article
- Generic eukaryotic core promoter prediction using structural features of DNA.Genome research · 2008Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Although the sequencing of the human genome has been completed, the number and identity of genes contained within it remains to be fully determined. We used LongSAGE to analyze 660,357 human transcripts from human brain mRNA and identified expression of 17,409 known genes and >15,000 different transcripts that were not annotated in genome databases. Analysis of a subset of these unannotated transcripts suggests that 85% were differentially expressed in various tissue types and that fewer than 20% would have been detected by ab initio gene predictions. These studies suggest that the human genome contains on the order of twice as many transcribed regions as are currently annotated and that experimental approaches will be required to fully elucidate the novel genes corresponding to these transcripts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.