ArticleGenome research2007
Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- SLPI in Prostate Cancer.Cancers · 2026Review
- Correlated Gene Copy Number Changes in a Seminal Fluid Protein Network inbioRxiv : the preprint server for biology · 2025Article
- Versatile whey acidic protein four-disulfide core domain proteins: biology and role in diseases.Frontiers in cell and developmental biology · 2024Review
- WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation.Cell death & disease · 2023Article
- Faster Rates of Molecular Sequence Evolution in Reproduction-Related Genes and in Species with Hypodermic Sperm Morphologies.Molecular biology and evolution · 2021Article
- Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice.Disease models & mechanisms · 2019Article
- Endless forms of sexual selection.PeerJ · 2019Article
- Article
- Effects of alcohol on c-Myc protein in the brain.Behavioural brain research · 2017Article
- Characterisation of urinary WFDC12 in small nocturnal basal primates, mouse lemurs (Microcebus spp.).Scientific reports · 2017Article
- Sperm competition risk drives plasticity in seminal fluid composition.BMC biology · 2015Article
- Transcriptome analysis of the hormone-sensing cells in mammary epithelial reveals dynamic changes in early pregnancy.BMC developmental biology · 2015Article
- Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection.Journal of virology · 2014Article
- Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila.Molecular biology and evolution · 2014Article
- Human epididymis protein 4 and secretory leukocyte protease inhibitor in vaginal fluid: relation to vaginal components and bacterial composition.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Rates of evolution of hominoid seminal proteins are correlated with function and expression, rather than mating system.Journal of molecular evolution · 2014Article
- Reproduction and immunity-driven natural selection in the human WFDC locus.Molecular biology and evolution · 2013Article
- Evolutionary Modeling of Genotype-Phenotype Associations, and Application to Primate Coding and Non-coding mtDNA Rate Variation.Evolutionary bioinformatics online · 2013Article
- Interacting proteins on human spermatozoa: adaptive evolution of the binding of semenogelin I to EPPIN.PloS one · 2013Article
- Sequence diversity of Pan troglodytes subspecies and the impact of WFDC6 selective constraints in reproductive immunity.Genome biology and evolution · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The initial comparison of the human and chimpanzee genome sequences revealed 16 genomic regions with an unusually high density of rapidly evolving genes. One such region is the whey acidic protein (WAP) four-disulfide core domain locus (or WFDC locus), which contains 14 WFDC genes organized in two subloci on human chromosome 20q13. WAP protease inhibitors have roles in innate immunity and/or the regulation of a group of endogenous proteolytic enzymes called kallikreins. In human, the centromeric WFDC sublocus also contains the rapidly evolving seminal genes, semenogelin 1 and 2 (SEMG1 and SEMG2). The rate of SEMG2 evolution in primates has been proposed to correlate with female promiscuity and semen coagulation, perhaps related to post-copulatory sperm competition. We mapped and sequenced the centromeric WFDC sublocus in 12 primate species that collectively represent four different mating systems. Our analyses reveal a 130-kb region with a notably complex evolutionary history that has included nested duplications, deletions, and significant interspecies divergence of both coding and noncoding sequences; together, this has led to striking differences of this region among primates and between primates and rodents. Further, this region contains six closely linked genes (WFDC12, PI3, SEMG1, SEMG2, SLPI, and MATN4) that show strong patterns of adaptive selection, although an unambiguous correlation between gene mutation rates and mating systems could not be established.
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