ArticleMolecular biology of the cell2007
Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Genome-wide meta-analysis identifies new susceptibility loci for migraine.Nature genetics · 2013Pooled it
- Exploring monocarboxylate transporter inhibition for cancer treatment.Exploration of targeted anti-tumor therapy · 2024Review
- Expression Patterns of Ezrin and AJAP1 and Clinical Significance in Breast Cancer.Frontiers in oncology · 2022Article
- AJAP1 expression modulates glioma cell motility and correlates with tumor growth and survival.International journal of oncology · 2018Article
- Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells.Biology open · 2017Article
- Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/βNature communications · 2017Article
- Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis.Cell death & disease · 2017Article
- Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile.Biology open · 2016Article
- The role of EMMPRIN in T cell biology and immunological diseases.Journal of leukocyte biology · 2015Review
- An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions.Journal of cell science · 2014Article
- AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization.CNS neuroscience & therapeutics · 2014Article
- A global profile of gene promoter methylation in treatment-naïve urothelial cancer.Epigenetics · 2014Article
- Novel three-dimensional in vitro models of ovarian endometriosis.Journal of ovarian research · 2014Article
- Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.Caries research · 2014Article
- Clathrin-independent endocytosis: a cargo-centric view.Experimental cell research · 2013Review
- Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.Nature genetics · 2013Article
- GWAS of dental caries patterns in the permanent dentition.Journal of dental research · 2013Article
- Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma.Molecular cancer research : MCR · 2012Article
- Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma.Chinese journal of cancer · 2011Article
- E-cadherin surface levels in epithelial growth factor-stimulated cells depend on adherens junction protein shrew-1.Molecular biology of the cell · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shrew-1 was previously isolated from an endometriotic cell line in our search for invasion-associated genes. It proved to be a membrane protein that targets to the basolateral membrane of polarized epithelial cells, interacting with E-cadherin-catenin complexes of adherens junctions. Paradoxically, the existence of adherens junctions is incompatible with invasion. To investigate whether shrew-1 can indeed influence cellular invasion, we overexpressed it in HT1080 fibrosarcoma cells. This resulted in enhanced invasiveness, accompanied by an increased matrix metalloprotease (MMP)-9 level in the supernatant, raising the question about the role of shrew-1 in this process. Logic suggested we looked for an interaction with CD147, a known promoter of invasiveness and MMP activity. Indeed, genetics-based, biochemical, and microscopy experiments revealed shrew-1- and CD147-containing complexes in invasive endometriotic cells and an interaction in epithelial cells, which was stronger in MCF7 tumor cells, but weaker in Madin-Darby canine kidney cells. In contrast to the effect mediated by overexpression, small interfering RNA-mediated down-regulation of either shrew-1 or CD147 in HeLa cells decreased invasiveness without affecting the proliferation behavior of HeLa cells, but the knockdown cells displayed decreased motility. Altogether, our results imply that shrew-1 has a function in the regulation of cellular invasion, which may involve its interaction with CD147.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.