ArticleMolecular biology of the cell2007
Diversification of function by different isoforms of conventionally shared RNA polymerase subunits.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review).Molecular medicine reports · 2026Review
- Comparative gut microbial enzyme functions in human amoebiasis: Implications for host-microbe interactions and veterinary parasitic models.Open veterinary journal · 2026Article
- Characterization of the dual functions of Leishmania CK1.2 in both the parasite and the macrophage.PloS one · 2026Article
- Imaging of genomic loci in Trypanosoma brucei using an optimised LacO-LacI system.Molecular and biochemical parasitology · 2023Article
- The RNA export factor TbMex67 connects transcription and RNA export in Trypanosoma brucei and sets boundaries for RNA polymerase I.Nucleic acids research · 2023Article
- Curvicollide D Isolated from the FungusInternational journal of molecular sciences · 2022Article
- An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes.Nature communications · 2022Article
- A nuclear enterprise: zooming in on nuclear organization and gene expression control in the African trypanosome.Parasitology · 2021Review
- Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids.Molecular microbiology · 2018Article
- Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.PLoS neglected tropical diseases · 2017Article
- Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit.Nucleic acids research · 2015Article
- Kinetoplastid Specific RNA-Protein Interactions in Trypanosoma cruzi Ribosome Biogenesis.PloS one · 2015Article
- Article
- TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomes.Nucleic acids research · 2013Article
- The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function.Eukaryotic cell · 2012Article
- Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei.PLoS pathogens · 2012Article
- Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes.Molecular and cellular biology · 2011Article
- Cell biology of the trypanosome genome.Microbiology and molecular biology reviews : MMBR · 2010Review
- Reconstructing the evolutionary history of the centriole from protein components.Journal of cell science · 2010Article
- Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea.Biology direct · 2009Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Eukaryotic nuclei contain three classes of multisubunit DNA-directed RNA polymerase. At the core of each complex is a set of 12 highly conserved subunits of which five--RPB5, RPB6, RPB8, RPB10, and RPB12--are thought to be common to all three polymerase classes. Here, we show that four distantly related eukaryotic lineages (the higher plant and three protistan) have independently expanded their repertoire of RPB5 and RPB6 subunits. Using the protozoan parasite Trypanosoma brucei as a model organism, we demonstrate that these distinct RPB5 and RPB6 subunits localize to discrete subnuclear compartments and form part of different polymerase complexes. We further show that RNA interference-mediated depletion of these discrete subunits abolishes class-specific transcription and hence demonstrates complex specialization and diversification of function by conventionally shared subunit groups.
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